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首页> 外文期刊>Research Journal of Biotechnology >Effect erf Medicinal Mushroom, Auricularia auricula-judae, polysaccharides against EAC cell lines
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Effect erf Medicinal Mushroom, Auricularia auricula-judae, polysaccharides against EAC cell lines

机译：erf药用蘑菇，金耳木耳，多糖对EAC细胞系的影响

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摘要

One of the major causes of mortality worldwide is cancer. Increasing research on herbal medicine has revealed its importance in treating many diseases including cancer. The present study was carried out to evaluate the antitumor activity of crude polysaccharide extract of Auricularia auricula-judae on Ehrlich Ascites Carcinoma (EAC) model in mice. After inoculation of EAC cells into mice, treatment with Auricularia auricula-judae (AAE) (200 mg/kg) was continued for 9 days. The effect of drug responsewas evaluated by the study of tumor growth response including study of hematological parameters, biochemical analysis, chromosomal disintegration assay and in vitro cytotoxicity. Experimental results revealed that the polysaccharide extract of Auricularia auricula-judae possesses significant anticancer activity due to the presence of polysaccharides like Beta-Glucans which may be in response to its cytotoxicity.
机译：全世界死亡的主要原因之一是癌症。越来越多的草药研究表明其在治疗包括癌症在内的许多疾病中的重要性。本研究旨在评价木耳粗多糖提取物对小鼠艾氏腹水癌（EAC）模型的抗肿瘤活性。将EAC细胞接种到小鼠中后，继续用Auricularia auricula-judae（AAE）（200 mg / kg）处理9天。通过研究肿瘤生长反应，包括研究血液学参数，生化分析，染色体崩解试验和体外细胞毒性，来评估药物反应的效果。实验结果表明，由于存在像β-葡聚糖这样的多糖，这可能是由于其细胞毒性而引起的，Auricularia auricula-judae的多糖提取物具有显着的抗癌活性。

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