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首页> 外文期刊>Reproductive biomedicine online >Inhibin A: marker for diagnosis of ectopic and early abnormal pregnancies.
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Inhibin A: marker for diagnosis of ectopic and early abnormal pregnancies.

机译：抑制素A：诊断异位和早期异常妊娠的标志物。

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A prospective case-control study was performed to determine whether inhibin A concentration is a clinically useful marker of ectopic pregnancy (EP). Inhibin A concentration in patients diagnosed with EP by laparoscopic and pathological findings (n = 17) was compared with that in missed miscarriage (n = 35), incomplete miscarriage (n = 14), spontaneous miscarriage (n = 5), threatened miscarriage (n = 6), normal pregnancy (n = 24) and non-pregnant controls (n = 20). The data were analysed using the Mann-Whitney U-test. EP yielded significantly lower inhibin A concentrations compared with normal pregnancy, 12.7 +/- 11.7 versus 237.3 +/- 125.9 pg/ml (P < 0.0002), and similar concentrations to non-pregnant controls (13.3 +/- 14.3 pg/ml). Inhibin A concentrations in abnormal pregnancies were significantly lower than in the normal pregnancy group: missed miscarriage 42.4 +/- 54.9 pg/ml (P < 0.0002); spontaneous miscarriage 47.5 +/- 55.6 pg/ml (P < 0.0002); and incomplete miscarriage 12.2 +/- 10.5 pg/ml (P < 0.0002). Threatened miscarriage was not statistically different to normal pregnancy (183.1 +/- 119.4 pg/ml). Human chorionic gonadotrophin concentrations in EP were not statistically significantly different compared with missed miscarriage and incomplete miscarriage. In conclusion, serum inhibin A concentration may be a reliable marker of EP.
机译：进行了一项前瞻性病例对照研究，以确定抑制素A的浓度是否是异位妊娠（EP）的临床有用标志。将通过腹腔镜和病理学检查诊断为EP的患者中的抑制素A浓度（n = 17）与漏诊流产（n = 35），不完全流产（n = 14），自发流产（n = 5），先兆流产（n = 5）进行了比较。 n = 6），正常妊娠（n = 24）和非妊娠对照组（n = 20）。使用Mann-Whitney U检验分析数据。与正常妊娠相比，EP产生的抑制素A浓度显着降低，分别为12.7 +/- 11.7和237.3 +/- 125.9 pg / ml（P <0.0002），并且与非妊娠对照组的浓度相似（13.3 +/- 14.3 pg / ml） 。异常妊娠中的抑制素A浓度显着低于正常妊娠组：流产漏诊42.4 +/- 54.9 pg / ml（P <0.0002）;自发流产47.5 +/- 55.6 pg / ml（P <0.0002）;和不完全流产12.2 +/- 10.5 pg / ml（P <0.0002）。先兆流产在统计学上与正常妊娠无统计学差异（183.1 +/- 119.4 pg / ml）。与错过的流产和不完全的流产相比，EP中人绒毛膜促性腺激素的浓度无统计学差异。总之，血清抑制素A浓度可能是EP的可靠标志。

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