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首页> 外文期刊>Reproductive biomedicine online >Aromatase inhibitors for female infertility: a systematic review of the literature.
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Aromatase inhibitors for female infertility: a systematic review of the literature.

机译：用于女性不育的芳香酶抑制剂：文献综述。

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摘要

Ovulation induction remains a milestone in the treatment of women with anovulatory infertility. Clomiphene citrate (CC) is considered the first line treatment for induction of ovulation in women with polycystic ovary syndrome (PCOS), while it may be used for ovulation induction in unexplained infertility. Aromatase inhibitors (AI) have been introduced as a new treatment option that could challenge CC for ovulation induction. A systematic review of the literature was conducted in order to highlight the efficacy and safety of AI in female infertility. Current data from randomized and non-randomized trials suggest that AI may have a role in ovulation induction regimens in PCOS patients, as well as for ovarian stimulation, since they achieve comparable clinical pregnancy rates to CC. Furthermore, when combined with gonadotrophins, AI improve the ovarian response of poor responders and reduce the gonadotrophin dose required. However, the current review is based on small trials with a limited number of patients. If solid data from future large adequately powered randomized trials support current evidence regarding efficacy and safety, AI might offer a new treatment choice for infertile women.
机译：诱导排卵仍然是治疗无排卵性不孕妇女的一个里程碑。柠檬酸克罗米芬（CC）被认为是诱导多囊卵巢综合征（PCOS）妇女排卵的一线治疗方法，但在无法解释的不育症中也可用于诱导排卵。芳香酶抑制剂（AI）已被引入作为一种新的治疗选择，可能会挑战CC诱导排卵。为了突出AI在女性不育症中的功效和安全性，对文献进行了系统的综述。来自随机和非随机试验的最新数据表明，AI可能在PCOS患者的排卵诱导方案以及卵巢刺激中起作用，因为它们的临床妊娠率与CC相当。此外，当与促性腺激素联合使用时，AI可改善反应迟钝的卵巢的反应，并减少所需的促性腺激素剂量。但是，当前的审查是基于针对少数患者的小型试验。如果来自未来大型，有足够能力的随机试验的可靠数据支持有关有效性和安全性的最新证据，那么AI可能为不育妇女提供新的治疗选择。

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