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首页> 外文期刊>Research journal of microbiology. >Taificidinl and taificidin2, two anti-microbial agents isolated from the fermentation broth of streptomyces roseodistaticus TA15 and Streptomyces lavendofoliae TA17
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Taificidinl and taificidin2, two anti-microbial agents isolated from the fermentation broth of streptomyces roseodistaticus TA15 and Streptomyces lavendofoliae TA17

机译：Taificidinl和taificidin2，两种分离自玫瑰链霉菌TA15和淡紫色链霉菌TA17的发酵液中的抗菌剂

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摘要

Isolation of antimicrobial agents from actinomycetes isolated from EL-Taif area, Kingdom of Saudi Arabia, two streptomyces isolates showed remarkable antimicrobial activity against tested organisms. The two isolates were previously identified according to the recommended keys as Streptomyces roseodistaticus TA15 and Streptomyces lavendofoliae TA17. The active metabolites of St. roseodistaticus TA15 and St. lavedofoliae TA17 were extracted by using different organic solvents, purified using both Thin Layer Chromatography (TLC) and column chromatography. The active compounds were concentrated and investigated for their physical characteristics and elemental, spectroscopic and biochemical analysis and their Minimum Inhibition Concentration (MIC) were determined. The cytopathic effect of the two antimicrobial agents on the vero cell virus, the neutralization test in monolayer cell cultures for antiviral test on coxasackie B4, hepatitis A and herpes simplex (cox B4, HAV and HSVI) viruses was also determined. Aim of this study is to identify the antimicrobial activity of actinomycetes extracts isolated from Saudi Arabia. We suggested the name Taificidin 1 and Taificidin 2 for the antimicrobial agent which extracted from St. roseodistaticus TA15 and from St. lavedofoliae TA17 as two active compounds isolated for first time from EL-Taif region, KSA.
机译：从沙特阿拉伯王国EL-Taif地区分离的放线菌中分离出抗菌剂，两种链霉菌分离株对被测生物显示出显着的抗菌活性。先前已根据推荐关键字将两个分离株鉴定为玫瑰链霉菌TA15和淡紫色链霉菌TA17。使用不同的有机溶剂提取玫瑰香静态玫瑰TA15和薰衣草玫瑰TA17的活性代谢物，并分别使用薄层色谱法（TLC）和柱色谱法进行纯化。浓缩活性化合物并研究其物理特性，并进行元素，光谱和生化分析，并确定其最低抑菌浓度（MIC）。还确定了两种抗微生物剂对Vero细胞病毒的细胞病变作用，单层细胞培养物中和测试中对柯萨奇B4，甲型肝炎和单纯疱疹病毒（cox B4，HAV和HSVI）的抗病毒测试。这项研究的目的是确定从沙特阿拉伯分离的放线菌提取物的抗菌活性。我们建议从抗菌肽TA15和从薰衣草TA17中提取的抗菌剂的名称为Taificidin 1和Taificidin 2，这是首次从EL-Taif地区KSA分离的两种活性化合物。

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