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首页> 外文期刊>Reproductive biomedicine online >Oestrogen and progesterone action on endometrium: A translational approach to understanding endometrial receptivity
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Oestrogen and progesterone action on endometrium: A translational approach to understanding endometrial receptivity

机译：雌激素和孕激素对子宫内膜的作用：一种理解子宫内膜容受性的转化方法

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Embryo attachment and implantation is critical to successful reproduction of all eutherian mammals, including humans; a better understanding of these processes could lead to improved infertility treatments and novel contraceptive methods. Experience with assisted reproduction, especially oocyte donation cycles, has established that despite the diverse set of hormones produced by the ovary in a cycle-dependent fashion, the sequential actions of only two of them, oestrogen and progesterone, are sufficient to prepare a highly receptive endometrium in humans. Further investigation on the endometrial actions of these two hormones is currently providing significant insight into the implantation process in women, strongly suggesting that an abnormal response to progesterone underlies infertility in some patients.
机译：胚胎的附着和植入对于包括人类在内的所有欧亚哺乳动物的成功繁殖至关重要。对这些过程的更好的了解可能会导致不育治疗和新的避孕方法得到改善。辅助生殖，特别是卵母细胞捐赠周期的经验表明，尽管卵巢以周期依赖的方式产生多种激素，但只有其中两种（雌激素和孕激素）的顺序作用足以制备高度接受性的激素。人类子宫内膜。目前，对这两种激素的子宫内膜作用的进一步研究为女性的着床过程提供了重要的见识，有力地表明，对黄体酮的异常反应是某些患者不育的基础。

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