Depletion of Aurora a leads to upregulation of FoxO1 to induce cell cycle arrest in hepatocellular carcinoma cells

LeeS.-Y.; LeeG.R.; WooD.-H.; ParkN.; ChaH.; MoonY.-H.; HanI.-S.

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Depletion of Aurora a leads to upregulation of FoxO1 to induce cell cycle arrest in hepatocellular carcinoma cells

机译：极光a的耗尽导致FoxO1上调以诱导肝癌细胞的细胞周期停滞

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Aurora A kinase has drawn considerable attention as a therapeutic target for cancer therapy. However, the underlying molecular and cellular mechanisms of the anticancer effects of Aurora A kinase inhibition are still not fully understood. Herein, we show that depletion of Aurora A kinase by RNA interference (RNAi) in hepatocellular carcinoma (HCC) cells upregulated FoxO1 in a p53-dependent manner, which induces cell cycle arrest. Introduction of an RNAi-resistant Aurora A kinase into Aurora A-knockdown cells resulted in downregulation of FoxO1 expression and rescued proliferation. In addition, silencing of FoxO1 in Aurora A-knockdown cells allowed the cells to exit cytostatic arrest, which, in turn, led to massive cell death. Our results suggest that FoxO1 is responsible for growth arrest at the G2/M phase that is induced by Aurora A kinase inhibition.

机译：作为癌症治疗的治疗靶标，Aurora A激酶引起了极大的关注。但是，对Aurora A激酶抑制作用的抗癌作用的潜在分子和细胞机制仍未完全了解。在这里，我们显示肝细胞癌（HCC）细胞中RNA干扰（RNAi）消耗Aurora A激酶以p53依赖性方式上调FoxO1，从而诱导细胞周期停滞。将耐RNAi的Aurora A激酶引入Aurora A敲低细胞导致FoxO1表达下调并挽救了增殖。此外，在Aurora A-knockdown细胞中使FoxO1沉默可使细胞退出抑制细胞生长的细胞停滞，进而导致大量细胞死亡。我们的结果表明FoxO1负责Aurora A激酶抑制诱导的G2 / M期生长停滞。

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《Cell cycle》 |2013年第1期|共9页
作者
LeeS.-Y.; LeeG.R.; WooD.-H.; ParkN.; ChaH.; MoonY.-H.; HanI.-S.;
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正文语种 eng
中图分类细胞生物学;
关键词
Aurora a; FoxO1; Growth arrest; Hepatocellular carcinoma; p53;

机译：极光a;FoxO1;生长停滞;肝细胞癌;p53;

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专利

1. Depletion of Aurora a leads to upregulation of FoxO1 to induce cell cycle arrest in hepatocellular carcinoma cells [J] . LeeS.-Y., LeeG.R., WooD.-H., Cell cycle . 2013,第1期

机译：极光a的耗尽导致FoxO1上调以诱导肝癌细胞的细胞周期停滞
2. A novel all-trans retinoic acid derivative 4-amino-2-trifluoromethyl-phenyl retinate inhibits the proliferation of human hepatocellular carcinoma HepG2 cells by inducing G0/G1 cell cycle arrest and apoptosis via upregulation of p53 and ASPP1 and downregulation of iASPP [J] . Liu Hui, Chen Feihu, Zhang Ling, Oncology reports . 2016,第1期

机译：一种新型的全反式维甲酸衍生物4-氨基-2-三氟甲基-苯基视黄酸酯通过上调p53和ASPP1并下调iASPP诱导G0 / G1细胞周期阻滞和凋亡，从而抑制人肝癌HepG2细胞的增殖。
3. p53-dependent upregulation of miR-16-2 by sanguinarine induces cell cycle arrest and apoptosis in hepatocellular carcinoma [J] . Beilei Zhang, Xinan Wang, Jiacong Deng, Cancer letters . 2019,第期

机译：Sanguinarine的MiR-16-2的P53依赖性上调诱导肝细胞癌细胞周期骤停和细胞凋亡
4. Zinc Oxide Nanoparticles Induce Apoptosis and Necrosis in Hepatocellular Carcinoma HepG2 Cells [C] . Satya Murthy Tadinada, Maria B. Lai, Vinay K. Idikuda, Annual NSTI nanotechnology conference and expo . 2013

机译：氧化锌纳米颗粒诱导肝癌细胞HepG2细胞凋亡和坏死。
5. Cannabinol Inhibits Proliferation and Induces Cell Cycle Arrest and Apoptosis in Glioblastoma, Hepatocellular Carcinoma and Breast Cancer Cells [D] . Zhong, Nuanying. 2020

机译：大麻素抑制胶质母细胞瘤，肝细胞癌和乳腺癌细胞中的增殖和诱导细胞周期停滞和凋亡
6. Depletion of Aurora A leads to upregulation of FoxO1 to induce cell cycle arrest in hepatocellular carcinoma cells [O] . Sun-Young Lee, Gong Rak Lee, Dong-Hyuk Woo, 2013

机译：极光A的消耗导致FoxO1上调从而诱导肝癌细胞的细胞周期停滞
7. >Knockdown of cyclooxygenase-2 leads to growth inhibition and cell cycle arrest in hepatocellular carcinoma cells [O] . Xiuhe Lv, Zhen Chen, Shaohua Li, 2019

机译：>环氧氧酶-2的敲低导致肝细胞癌细胞中生长抑制和细胞周期停滞

Depletion of Aurora a leads to upregulation of FoxO1 to induce cell cycle arrest in hepatocellular carcinoma cells

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