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首页> 外文期刊>Regulatory Toxicology and Pharmacology: RTP >Subchronic (13-week) toxicity and prenatal developmental toxicity studies of dietary astaxanthin in rats
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Subchronic (13-week) toxicity and prenatal developmental toxicity studies of dietary astaxanthin in rats

机译：日粮虾青素在大鼠中的亚慢性（13周）毒性和产前发育毒性研究

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摘要

Two studies examined the effects of dietary astaxanthin on Hanlbm Wistar (SPF) rats. Male and female rats receiving astaxanthin concentrations up to 1.52% of the feed for 13 weeks showed no evidence of toxicity; no effects were noted in the offspring of female rats exposed to astaxanthin at up to 139% of the feed during the period of organogenesis (GD 7-16). Discoloration of the feces and yellow pigmentation of adipose tissue was seen in the 13-week study, an intrinsic property of the substance, and not a sign of toxicity. Differences between the control and astaxanthin groups, some of which reached statistical significance, were generally sporadic (Le., transient and/or not related to astaxanthin concentration) and not considered of biological or toxicological significance. Blood cholesterol levels, for example, were greater in animals receiving astaxanthin for 13 weeks, but remained within the normal range. The highest dietary concentration of astaxanthin in each of the studies is proposed as a no-observable-adverse-effect level (NOAEL). Specifically, 1.52% for the 13-week study, corresponding to a mean intake of 1033 mg/kg bw/day (range: 880-1240 mg/kg bw/day), and 139% for the developmental toxicity study, corresponding to a mean intake of approximately 830 mg/kg bw/day (range: 457-957 mg/kg bw/day). (C) 2015 Elsevier Inc. All rights reserved.
机译：两项研究检查了饮食中虾青素对Hanlbm Wistar（SPF）大鼠的影响。雄性和雌性大鼠虾青素浓度最高达到饲料的1.52％，持续13周时，没有显示毒性的迹象。在器官发生期间，未观察到雌虾暴露于虾青素的饲料中的影响高达其饲料的139％（GD 7-16）。在为期13周的研究中，发现粪便变色和脂肪组织的黄色色素沉着是该物质的内在特性，而不是毒性的迹象。对照组和虾青素组之间的差异（其中一些达到统计学意义）通常是零星的（Le。，瞬时的和/或与虾青素浓度无关），并且没有生物学或毒理学意义。例如，接受虾青素治疗13周的动物的血液胆固醇水平较高，但仍处于正常范围内。在每项研究中，虾青素的最高饮食浓度都被认为是不可观察到的不良反应水平（NOAEL）。具体而言，为期13周的研究占1.52％，平均摄入量为1033 mg / kg bw /天（范围：880-1240 mg / kg bw /天），而发育毒性研究为139％，对应于平均摄入量约为830 mg / kg bw /天（范围：457-957 mg / kg bw /天）。 （C）2015 Elsevier Inc.保留所有权利。

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