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首页> 外文期刊>Cell cycle >Cell cycle regulation in hematopoietic stem/progenitor cells.
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Cell cycle regulation in hematopoietic stem/progenitor cells.

机译：造血干/祖细胞中的细胞周期调节。

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摘要

Hematopoietic stem cells (HSCs) are characterized by pluripotentiality and a capacity for self-renewal. In order to both maintain a supply of mature blood cells and not to exhaust HSCs throughout the lifespan of the organism, most HSCs remain quiescent and only a limited number enter the cell cycle. In HSCs, the cell cycle is crucially regulated by external factors such as cytokines and interactions with stromal cells and the extracellular matrix (ECM) in the bone marrow (BM) microenvironment. In addition, intrinsic transcription factors expressed in HSCs, including c-Myb, GATA-2, HOX family proteins, and Bmi-1, also control their growth through their effect on gene transcription. In terms of the particular roles in regulation of the cell-cycle, p21WAF1 (p21) and p27KIP1 (p27) were shown to maintain the quiescence of HSCs and of progenitor cells, respectively, thereby governing their available pool sizes. Also, p16INK4A (p16) and p15INK4B (p15) are thought to act as tumor suppressors, since their inactivation and/or deletion are observable in various types of hematologic malignancies. These results make evident that appropriate cell cycle control, particularly at the early stage of stem/progenitor cells, is required for maintaining normal hematopoiesis.
机译：造血干细胞（HSCs）具有多能性和自我更新的能力。为了既维持成熟血细胞的供应又不耗尽生物整个生命周期中的HSC，大多数HSC保持静止，只有有限数量的HSC进入细胞周期。在HSC中，细胞周期受外部因素（例如细胞因子以及与骨髓（BM）微环境中的基质细胞和细胞外基质（ECM）的相互作用）的关键调控。此外，HSC中表达的内在转录因子，包括c-Myb，GATA-2，HOX家族蛋白和Bmi-1，也通过它们对基因转录的作用来控制它们的生长。根据在细胞周期调控中的特殊作用，p21WAF1（p21）和p27KIP1（p27）被证明分别维持HSC和祖细胞的静止，从而控制它们的可用池大小。同样，p16INK4A（p16）和p15INK4B（p15）被认为是肿瘤抑制因子，因为在各种类型的血液系统恶性肿瘤中均可观察到它们的失活和/或缺失。这些结果表明，维持正常的造血需要适当的细胞周期控制，特别是在干/祖细胞的早期阶段。

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