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首页> 外文期刊>Regulatory Toxicology and Pharmacology: RTP >Development of an occupational exposure limit for n-propylbromide using benchmark dose methods.
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Development of an occupational exposure limit for n-propylbromide using benchmark dose methods.

机译：使用基准剂量法制定正丙基溴的职业接触限值。

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This paper presents the development of an occupational exposure level (OEL) for n-propylbromide (nPB) using benchmark dose methods. nPB is a non-ozone depleting solvent, proposed under the Significant New Alternatives Policy (SNAP) for use as a precision vapor degreaser. OELs have generally been developed on the basis of a NOAEL or LOAEL and application of uncertainty factors; this paper represents a departure from historic methods. Six recently completed toxicological studies were critically reviewed to identify (1) toxicologically significant endpoints, (2) dose-response information on these endpoints, and (3) uncertainties and limitations associated with the studies. Dose-response data were compiled and entered into the USEPA's benchmark dose software for calculation of a benchmark dose (BMD) and a benchmark dose low (BMDL). Once values were estimated for all relevant studies, they were then incorporated into a weight-of-evidence approach to develop a single BMD and BMDL representative of nPB. This approach is similar to that recently taken by USEPA to develop their own recommended OEL for nPB. USEPA's approach is compared and contrasted with ours, particularly in relation to the application of uncertainty factors (UFs) to generate a final OEL. There are no published criteria for application of UFs in developing an OEL. Although USEPA recommends utilizing a UF of 9, based on intraspecies variability and pharmacokinetic differences between rats and humans, to meet the goal of protecting healthy adult in a workplace setting, no uncertainty factor was deemed necessary for nPB in this paper. Therefore, the BMDL was recommended as the OEL.
机译：本文介绍了使用基准剂量法开发正丙基溴（nPB）的职业暴露水平（OEL）的方法。 nPB是一种重要的新型替代品政策（SNAP）中提出的一种非臭氧消耗溶剂，可用作精密的蒸汽脱脂剂。 OEL通常是基于NOAEL或LOAEL以及不确定因素的应用而开发的;本文代表了对历史方法的偏离。对六项最近完成的毒理学研究进行了严格审查，以识别（1）具有毒理学意义的终点，（2）这些终点的剂量反应信息以及（3）与研究相关的不确定性和局限性。汇编剂量响应数据并将其输入到USEPA的基准剂量软件中，以计算基准剂量（BMD）和低基准剂量（BMDL）。一旦对所有相关研究的值进行了估算，然后将其合并到证据权重法中，以开发出代表nPB的单个BMD和BMDL。这种方法类似于USEPA最近为nPB开发自己的推荐OEL所采用的方法。 USEPA的方法与我们的方法进行了比较和对比，特别是在应用不确定性因子（UFs）生成最终OEL方面。在开发OEL时，没有公开的应用UF的标准。尽管USEPA建议根据种内变异性和大鼠与人类之间的药代动力学差异，使用UF为9，以达到在工作场所保护健康成年的目标，但本文认为nPB不需要不确定性因素。因此，建议将BMDL作为OEL。

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