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首页> 外文期刊>Regulatory Toxicology and Pharmacology: RTP >Absence of reproductive and developmental toxicity in rats following exposure to a 20-kHz or 60-kHz magnetic field
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Absence of reproductive and developmental toxicity in rats following exposure to a 20-kHz or 60-kHz magnetic field

机译：暴露于20-kHz或60-kHz磁场后，大鼠无生殖和发育毒性

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摘要

The use of intermediate frequency (IF) magnetic fields (MFs) in occupational equipment and domestic appliances, such as inductive heating cookers, is increasing. The WHO indicated a lack of scientific evidence needed to assess the health risk of exposure to IF MFs. Male and female rats (24/group) were exposed to a 20. kHz, 0.2. mT(rms) or 60. kHz, 0.1. mT(rms) sinusoidal MF for 22. h/day from 14. days prior to and during mating. Copulated females were exposed until gestation day 7 and sacrificed thereafter. Mated males were sacrificed to examine MF exposure effects on spermatogenesis. Reproductive examinations were blinded, and experiments were duplicated per frequency to ensure reproducibility. No statistically significant, exposure-related changes were found in the estrous cycle, copulation and fertility indices, numbers of corpora lutea and implantation sites, or pre- and postimplantation loss. No reproducible changes were observed in sperm count, motility, or morphological abnormality, or in the weights of testes and epididymides after MF exposure. No significant abnormalities were observed in gross pathology or histopathology of the uterus, ovary, testis, and epididymis in the MF- or sham-exposed groups. MF exposure during the preimplantation period was not toxic to fertility or early embryogenesis under the experimental conditions.
机译：越来越多的中频（IF）磁场（MF）在职业设备和家用电器（例如感应加热炊具）中使用。世卫组织表示，缺乏评估暴露于中频MF的健康风险所需的科学证据。雄性和雌性大鼠（24只/组）暴露于20 kHz，0.2。 mT（rms）或60. kHz，0.1。从交配前和交配开始的14天开始，mT（rms）正弦MF持续22 h / day。将交配的雌性暴露直至妊娠第7天，然后处死。处死交配的雄性以检查MF暴露对精子发生的影响。生殖检查不知情，每个频率重复实验以确保可重复性。在发情周期，交配和生育指数，黄体和着床部位的数量或着床前后，均未发现与暴露有关的统计学显着变化。 MF暴露后，精子数量，运动力或形态异常，或睾丸和附睾重量均未见可重复的变化。在MF或假手术组中，未观察到子宫，卵巢，睾丸和附睾的总体病理或组织病理学的明显异常。在实验条件下，植入前的MF暴露对生育能力或早期胚胎发生没有毒性。

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