TNF signaling gets FLIPped off: TNF-induced regulation of FLIP.

Rushworth SA; Taylor A; Langa S; MacEwan DJ

首页> 外文期刊>Cell cycle >TNF signaling gets FLIPped off: TNF-induced regulation of FLIP.

【24h】

TNF signaling gets FLIPped off: TNF-induced regulation of FLIP.

机译：TNF信号被FLIP清除：TNF诱导的FLIP调节。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

One of the major guardians of death receptor mediated programmed cell death is FLIP (Fas-associated protein with death domain-like IL-1beta-converting enzyme (FLICE) inhibitory protein). As an important modulator of apoptosis, FLIP regulates life and death in various types of normal cells and tissues, such as lymphoid cells, and renders resistance to death receptor-mediated apoptosis in many types of tumor cells. Therefore, understanding the signals that control FLIP is vital to understanding and controlling diseases such as cancer. Here, we discuss the mechanisms that regulate FLIP activation by tumor necrosis factor (TNF), and their functional significance in regulating apoptotic processes.

机译：死亡受体介导的程序性细胞死亡的主要监护人之一是FLIP（具有死亡域样IL-1beta转换酶（FLICE）抑制蛋白的Fas相关蛋白）。作为凋亡的重要调节剂，FLIP调节各种正常细胞和组织（例如淋巴样细胞）中的生命和死亡，并在许多类型的肿瘤细胞中对死亡受体介导的凋亡产生抗性。因此，了解控制FLIP的信号对于理解和控制癌症等疾病至关重要。在这里，我们讨论了调节肿瘤坏死因子（TNF）激活FLIP的机制，以及它们在调节细胞凋亡过程中的功能意义。

著录项

来源
《Cell cycle》 |2008年第2期|共6页
作者
Rushworth SA; Taylor A; Langa S; MacEwan DJ;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类细胞生物学;
关键词
Animals; Apoptosis; CASP8 and FADD-Like Apoptosis Regulating Protein; Humans; 动物; 脱噬作用; 蛋白质亚型; 信号传递;

机译：Animals;Apoptosis;CASP8 and FADD-Like Apoptosis Regulating Protein;Humans;动物;脱噬作用;蛋白质亚型;信号传递;

相似文献

外文文献
中文文献
专利

1. BCL-XL regulates TNF-α-mediated cell death independently of NF-кB,FLIP and IAPs [J] . Raffaella Gozzelino, Nahuai Badiola, Daniel Sanchis, 细胞研究（英文版） . 2008,第010期
2. BCL-XL regulates TNF-α-mediated cell death independently of NF-κB, FLIP and IAPs [J] . Raffaella Gozzelino, Carme Sole, Nuria Llecha, 细胞研究：英文版 . 2008,第010期
3. TNF signaling gets FLIPped off: TNF-induced regulation of FLIP. [J] . Rushworth SA, Taylor A, Langa S, Cell cycle . 2008,第2期

机译：TNF信号被FLIP清除：TNF诱导的FLIP调节。
4. cAMP activated protein kinase (PKA) plays role in regulation of TNF-induced tumor necrosis factor receptor type I (TNFR1) signaling [J] . Hapil F. Z., Ertosun M. G., Copuroglu F. E., The FEBS journal . 2016,第Suppla1期

机译：cAMP激活蛋白激酶（PKA）在TNF诱导的I型肿瘤坏死因子受体（TNFR1）信号传导中发挥作用
5. IRF9 Affects the TNF-Induced Phenotype of Rheumatoid-Arthritis Fibroblast-Like Synoviocytes via Regulation of the SIRT-1/NF-kappa B Signaling Pathway [J] . Jiang Fan, Zhou Hong-Yi, Zhou Li-Fang, Cells tissues organs . 2020,第2a3期

机译：IRF9通过调节SIRT-1 / NF-Kappa发信号通路的调节影响TNF诱导的类风湿性关节炎成纤维细胞样胶质细胞的表型
6. Analysis of Tissue Distribution of TNF-α, TNF-α-Receptors, and the Activating TNF-α-Converting Enzyme Suggests Activation of the TNF-α System in the Aging Intervertebral Disc [C] . BEATRICE E. BACHMEIER, ANDREAS G. NERLICH, CHRISTOPH WEILER, Meeting on Cell Signaling World: Signal Transduction Pathways as Therapeutic Targets . 2007

机译：肿瘤坏死因子-α，肿瘤坏死因子-α-受体和活化的肿瘤坏死因子-α转换酶的组织分布分析表明，在老化的椎间盘中肿瘤坏死因子-α系统的激活。
7. Hemodynamic regulation of endothelial cell gene expression: Effects of p65 expression level on constitutive and TNFα induced NF-κB signalling [D] . Won, Doyon 2009

机译：血液动力学调节内皮细胞基因表达：p65表达水平对本构和TNFα诱导的NF-κB信号传导的影响
8. FLIP regulation of HO-1 and TNF signalling in human acute myeloid leukemia provides a unique secondary anti-apoptotic mechanism [O] . Stuart A Rushworth, Lyubov Zaitseva, Susana Langa, 2010

机译：FLIP对人急性髓性白血病中HO-1和TNF信号的调控提供了独特的继发性抗凋亡机制
9. FLIP regulation of HO-1 and TNF signalling in human acute myeloid leukemia provides a unique secondary anti-apoptotic mechanism [O] . Rushworth, Stuart A, Zaitseva, Lyubov, Langa, Susana, 2010

机译：FLIP对人急性髓性白血病中HO-1和TNF信号的调控提供了独特的继发性抗凋亡机制

TNF signaling gets FLIPped off: TNF-induced regulation of FLIP.

摘要

著录项

相似文献

相关主题

期刊订阅