...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cell cycle >Targeted cancer therapy: what if the driver is just a messenger?
【24h】

Targeted cancer therapy: what if the driver is just a messenger?

机译：靶向癌症治疗：如果驾驶员只是使者，该怎么办？

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

"Shoot the driver" is the paradigm of targeted cancer therapy. However, resistance to targeted inhibitors of signaling pathways is a major problem. In part the redundancy of signaling networks can bypass targeted inhibitors and thereby reduce their biological effect. In this case the driver turns out to be one of several potential messengers and is easily replaced. Cocktails of multiple targeted inhibitors are an obvious solution. This is limited, however, by the lack of potent inhibitors and may also produce increased toxicity. Therefore we explored the direct blockade of a key biological activity downstream from multiple converging oncogenic signals. Specifically, several oncogenic signaling pathways including AKT, MAPK and PIM kinase signals converge on the activation of cap-dependent translation. In cancer cells, aberrant activation of cap-dependent translation favors the increased expression of short-lived oncoproteins like c-MYC, MCL1, CYCLIN D1 and the PIM kinases. Intriguingly, cancer cells are especially sensitive to even temporary reductions in these proteins. We will discuss our findings concerning translational inhibitor therapy in cancer.
机译：“射击驾驶员”是针对性癌症治疗的范例。然而，对信号传导途径的靶向抑制剂的抗性是主要问题。信号网络的冗余部分可以绕过靶向抑制剂，从而降低其生物学效应。在这种情况下，驾驶员实际上是几个潜在的使者之一，并且很容易更换。多种靶向抑制剂的混合物是一个显而易见的解决方案。然而，这由于缺乏有效的抑制剂而受到限制，并且还可能产生增加的毒性。因此，我们探索了多个聚合致癌信号下游的关键生物学活性的直接阻断。具体而言，包括AKT，MAPK和PIM激酶信号在内的几种致癌信号通路都集中在cap依赖性翻译的激活上。在癌细胞中，帽依赖性翻译的异常激活有利于短时癌蛋白如c-MYC，MCL1，CYCLIN D1和PIM激酶的表达增加。有趣的是，癌细胞对这些蛋白质的暂时减少特别敏感。我们将讨论有关癌症中转化抑制剂治疗的发现。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号