Knocking down hYVH1/DUSP12 in human cells results in cell cycle arrest, as revealed by the striking increase in cells with G_0/G_1 DNA content following siRNA treatment. This result was further reiterated by a complementary experiment, in which ectopic hYVH1/DUSP12 expression led to arrest at the next checkpoint, with a decrease in G_0/_1G, population and a matched increase in G_2/M cell population.These interesting observations are outlined in the May 15th issue of Cell Cycle in a report by Kozarova et al. Together, they unveil a new dramatic role for hYVH1/DUSP12 at two critical checkpoints of the cell cycle that comes on the heels of a newly identified role of YVH1/ DUSP12 in eukaryotes ribosome biogenesis.hYVH1/DUSP12 is member of the dual-specificity phosphatases (DUSPs), a heterogeneous group that belongs to the protein tyrosinephosphatase(PTP)superfamily. Based on sequence similarity, the DUSP group should be subdivided in seven subgroups: slingshots, PRLs, CDC14s, PTENs, myotubularins, MKPs and atypical dual-specificity phosphatases.
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