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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >The two edges of the ATM sword: co-operation between repair and checkpoint functions.
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The two edges of the ATM sword: co-operation between repair and checkpoint functions.

机译：ATM剑的两个优势：维修和检查点功能之间的合作。

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摘要

ATM is a central component of a signal transduction process that responds to DNA double strand breaks (DSBs) ultimately effecting cell cycle checkpoint arrest and/or apoptosis. Recent studies have shown that ATM also regulates a mechanism of processing a subset of DNA ends that appear to be difficult to ligate, since they are rejoined with slow kinetics in control cells. In the absence of this process, which involves the nuclease, Artemis, the DSBs either remain unrejoined or potentially undergo misrejoining. Thus, ATM's checkpoint function specifically facilitates its repair function. Here, we discuss the contribution of this novel function of ATM to survival after ionising irradiation and to cancer avoidance. We suggest that ATM's strength as a damage response protein lies in the co-ordination of its repair and checkpoint functions making a razor sharp knife out of two blunter edges.
机译：ATM是信号转导过程的重要组成部分，可对DNA双链断裂（DSB）作出反应，最终影响细胞周期检查点的停滞和/或凋亡。最近的研究表明，ATM还调节处理难以连接的DNA末端子集的机制，因为它们在控制细胞中以缓慢的动力学重新结合。在没有涉及核酸酶Artemis的这一过程的情况下，DSB要么保持未结合状态，要么可能发生错接。因此，ATM的检查点功能特别有助于其修复功能。在这里，我们讨论了这种ATM新功能对电离辐射后的存活率和避免癌症的作用。我们建议ATM作为伤害反应蛋白的优势在于其修复和检查点功能的协调，使剃须刀锋利地从两个钝角中切出。

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