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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Tumor lactate content predicts for response to fractionated irradiation of human squamous cell carcinomas in nude mice.
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Tumor lactate content predicts for response to fractionated irradiation of human squamous cell carcinomas in nude mice.

机译：肿瘤中的乳酸含量预示着对裸鼠中人鳞状细胞癌分级照射的反应。

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BACKGROUND AND PURPOSE: The present study was performed to test the hypothesis that lactate accumulation correlates with the radioresistance of malignant tumors due to the radical scavenging capacity of lactate or metabolic intermediates of glycolysis, such as pyruvate. MATERIALS AND METHODS: Five human head and neck squamous cell carcinoma cell lines (HNSCCs) xenografted in nude mice were treated with a clinically relevant irradiation protocol with 30 fractions within 6 weeks. The radiation dose necessary to locally control 50% of the tumors (TCD50) ranged from 47.4 to 129.8 Gy. Concentrations of glucose, lactate, and ATP in viable tumor regions as potential indicators of glycolytic activity were assessed with structure-associated quantitative bioluminescence imaging. RESULTS: Mean lactate concentrations of the different tumor cell lines were in the range of 7.3-25.9 micromol/g. TCD50 values were positively correlated with tumor lactate levels (R = 0.9824, p = 0.0028). CONCLUSIONS: The data obtained support the hypothesis that tissue lactate content correlates with radioresistance in solid human tumors. Furthermore, the results suggest that tumor lactate content determined non-invasively by proton magnetic resonance spectroscopy imaging may be used to predict for radioresistance of malignancies in the clinic; the data also imply that transient inhibition of glycolysis during treatment might possibly sensitize tumors to irradiation.
机译：背景与目的：进行本研究以检验以下假设：乳酸的自由基清除能力或糖酵解的代谢中间产物（如丙酮酸）会导致乳酸积累与恶性肿瘤的放射抵抗相关。材料与方法：用临床相关的辐照方案在6周内用临床相关的辐照方案对裸鼠中异种移植的5例人头颈部鳞状细胞癌细胞系（HNSCC）进行了处理。局部控制50％肿瘤所需的辐射剂量（TCD50）为47.4至129.8 Gy。通过与结构相关的定量生物发光成像，评估了活的肿瘤区域中葡萄糖，乳酸和ATP的浓度，作为糖酵解活性的潜在指标。结果：不同肿瘤细胞系的平均乳酸浓度在7.3-25.9 micromol / g的范围内。 TCD50值与肿瘤乳酸水平呈正相关（R = 0.9824，p = 0.0028）。结论：所获得的数据支持假说，即组织乳酸盐含量与实体人肿瘤中的放射抵抗有关。此外，结果表明通过质子磁共振波谱成像非侵入性确定的肿瘤乳酸盐含量可用于预测临床中恶性肿瘤的放射抗性。该数据还暗示在治疗过程中糖酵解的短暂抑制可能会使肿瘤对放射线敏感。

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