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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Evaluating predictive factors for determining enteral nutrition in patients receiving radical radiotherapy for head and neck cancer: a retrospective review.
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Evaluating predictive factors for determining enteral nutrition in patients receiving radical radiotherapy for head and neck cancer: a retrospective review.

机译：评价确定接受根治性放疗的头颈癌患者肠内营养的预测因素：回顾性回顾。

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BACKGROUND AND PURPOSE: To identify objective pre-treatment clinical parameters that could be used to predict for patients at high risk of requiring enteral tube feeding prior to head and neck radiotherapy. PATIENTS AND METHODS: A retrospective study was conducted on 160 consecutive patients attending for radiotherapy assessment. Regression analysis was used to determine various pre-treatment nutritional and tumour specific parameters associated with the use of enteral nutrition either before (prophylactic) or during (reactive) radiotherapy (RT). The significant parameters identified were then selected into categorical variables and compared between those who needed reactive enteral nutrition and the remainder of the group who did not. These results were used to generate predictive factors that could be used to identify those at high risk of malnutrition during RT for whom early or prophylactic enteral nutrition should be considered. RESULTS: Fifty patients required enteral feeding of which 60% required this prior to radiotherapy. Multivariate analysis identified the following factors to be significant--body mass index, performance status (PS), advanced stage, pre-treatment weight loss, low serum albumin and protein, age, and smoking. The most significant categorical predictive parameters for reactive enteral feeding were stage 3-4 disease, PS 2-3, and smoking >20/day. The combination of these factors predicted a 75% chance of needing enteral nutrition. CONCLUSION: Nutritional assessment is important prior to radiotherapy and is multifactorial. Using a combination of relatively simple and objective parameters, (performance status, smoking and disease stage) it is possible to identify those at high risk of needing enteral nutrition prior to starting RT.
机译：背景与目的：确定客观的治疗前临床参数，这些参数可用于预测在头颈部放疗前需要肠管进食的高风险患者。病人和方法：回顾性研究进行了160例连续参加放射治疗评估的患者。回归分析被用来确定在放疗（RT）之前（预防）或放疗（RT）期间与使用肠内营养相关的各种治疗前营养和肿瘤特异性参数。然后，将识别出的重要参数选择为分类变量，并在需要反应性肠内营养的人群和其余不需要反应性肠内营养的人群之间进行比较。这些结果可用于产生预测因素，这些因素可用于确定在RT期间营养不良高风险人群中应考虑早期或预防性肠内营养的人群。结果：50名患者需要肠内喂养，其中60％的患者需要在放疗前进行肠内喂养。多变量分析确定了以下重要因素：体重指数，运动状态（PS），晚期，治疗前体重减轻，血清白蛋白和蛋白质低，年龄和吸烟。对于肠内反应性喂养而言，最重要的分类预测参数是3-4期疾病，PS 2-3和吸烟> 20 /天。这些因素共同预测了需要肠内营养的机会为75％。结论：营养评估在放疗前很重要，并且是多因素的。使用相对简单和客观的参数（运动状态，吸烟和疾病阶段）的组合，可以在开始RT之前确定那些需要肠内营养的高风险人群。

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