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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >The influence of fractionated radiation therapy on plasma vascular endothelial growth factor (VEGF) concentration in dogs with spontaneous tumors and its impact on outcome.
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The influence of fractionated radiation therapy on plasma vascular endothelial growth factor (VEGF) concentration in dogs with spontaneous tumors and its impact on outcome.

机译：分次放射治疗对自发性肿瘤犬血浆血管内皮生长因子（VEGF）浓度的影响及其对预后的影响。

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BACK GROUND AND PURPOSE: Vascular endothelial growth factor (VEGF), a specific pro-angiogenic factor is proposed to be involved in cancer progression and resistance to radiation therapy by promoting angiogenesis and by protecting endothelial cells from radiation induced apoptosis. The aim of this study, was first to assess the influence of ionizing radiation on plasma VEGF concentration in spontaneous canine tumors during fractionated radiation therapy with curative or palliative intent and second to analyze plasma VEGF concentration as predictor for treatment outcome. PATIENTS AND METHODS: For plasma VEGF analysis a human VEGF enzyme linked immunosorbent assay was used. Sixty dogs with various tumor types were included in this study. Dogs were irradiated with either low dose per fx (3-3.5Gy per fraction, total dose: 42-49Gy, group A: curative intent) or high dose per fx (6-8Gy per fraction, total dose: 24-30Gy, group B: palliative intent). Blood samples were taken before and after dose application at certain time points during therapy. Follow-up evaluation was performed for analysis of time to treatment failure and survival. RESULTS: Repeated measures analysis showed no increase of plasma VEGF in dogs treated with fractionated radiation therapy (group A and B). Dichotomizing baseline plasma VEGF into two groups with high and low plasma VEGF, resulted in shorter time to treatment failure in dogs with high plasma VEGF levels (TTF, group A: P=0.038, group B: P=0.041). CONCLUSIONS: This study demonstrated that dogs with a plasma VEGF level higher than 5pg/ml had a poorer outcome after radiation therapy. It is therefore, suggested, to use plasma VEGF as predictor for treatment outcome in radiation therapy.
机译：背景和目的：血管内皮生长因子（VEGF）是一种特定的促血管生成因子，通过促进血管新生并保护内皮细胞免于辐射诱导的凋亡而参与癌症的发展和对放射治疗的抵抗力。这项研究的目的是首先评估具有根治性或姑息性目的的分级放疗期间电离辐射对自发性犬肿瘤血浆VEGF浓度的影响，其次分析血浆VEGF浓度作为治疗结果的预测指标。患者和方法：对于血浆VEGF分析，使用人VEGF酶联免疫吸附测定。这项研究包括了六十只具有各种肿瘤类型的狗。用低剂量/ fx（每组分3-3.5Gy，总剂量：42-49Gy，A组：治愈意图）或高剂量/ fx（6-8Gy /组分，总剂量：24-30Gy，组）照射狗B：姑息性意图）。在治疗期间的某些时间点，在剂量应用之前和之后采集血液样本。进行随访评估以分析治疗失败和生存时间。结果：重复测量分析显示，采用分级放射治疗的犬（A组和B组）血浆VEGF没有增加。将血浆血浆VEGF分为高血浆和低血浆两组，导致血浆VEGF水平高的犬的治疗失败时间缩短（TTF，A组：P = 0.038，B组：P = 0.041）。结论：这项研究表明血浆VEGF水平高于5pg / ml的犬在放疗后的预后较差。因此，建议使用血浆VEGF作为放射治疗中治疗结果的预测因子。

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