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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Second cancers in children treated with modern radiotherapy techniques.
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Second cancers in children treated with modern radiotherapy techniques.

机译：用现代放射治疗技术治疗的儿童的第二种癌症。

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BACKGROUND AND PURPOSE: The scattered radiation from the treatment volume might be more significant for children than for adults and, as a consequence, modern radiotherapy treatment techniques such as IMRT and passive proton therapy could potentially increase the number of secondary cancers. In this report, secondary cancer risk resulting from new treatment technologies was estimated for an adult prostate patient and a child. MATERIAL AND METHODS: The organ equivalent dose (OED) concept with a linear-exponential, a plateau and a linear dose-response curve was applied to dose distributions of an adult prostate patient and a child with a rhabdomyosarcoma of the prostate. Conformal radiotherapy, IMRT with 6MV photons and proton therapy were planned. OED (cancer risk) was estimated for the whole body, the rectum and the bladder. In addition, relative cumulative risk was calculated. RESULTS: Secondary cancer risk in the adult is not more than 15% it increased when IMRT or passive proton therapy was comparedto conventional treatment planning. In the child, risk remains practically constant or was even reduced for proton therapy. The cumulative risk in the child relative to that in the adult can be as large as 10-15. CONCLUSIONS: By a comparison between an adult patient and a child treated for a disease of the prostate, it was shown that modern radiotherapy techniques such as IMRT and proton therapy (active and passive) do not increase the risk for secondary cancers.
机译：背景与目的：治疗体积的散布辐射对于儿童而言可能比对成年人更为重要，因此，现代放射疗法（例如IMRT和被动质子疗法）可能会增加继发性癌症的数量。在该报告中，估计了成年前列腺患者和儿童因新治疗技术而导致的继发性癌症风险。材料与方法：将具有线性指数，平稳期和线性剂量反应曲线的器官等效剂量（OED）概念应用于成年前列腺患者和患有前列腺横纹肌肉瘤的儿童的剂量分布。计划进行保形放射治疗，6MV光子的IMRT和质子治疗。估计整个身体，直肠和膀胱的OED（致癌风险）。此外，还计算了相对累积风险。结果：将IMRT或被动质子治疗与常规治疗计划相比，成人继发癌症的风险不超过15％。在儿童中，质子治疗的风险实际上保持不变，甚至降低了。与成人相比，儿童的累积风险可能高达10-15。结论：通过比较成年患者和接受前列腺疾病治疗的儿童，表明现代放射治疗技术，例如IMRT和质子治疗（主动和被动）不会增加继发癌症的风险。

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