...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >The effect of anaemia on efficacy and normal tissue toxicity following radiotherapy for locally advanced squamous cell carcinoma of the head and neck.
【24h】

The effect of anaemia on efficacy and normal tissue toxicity following radiotherapy for locally advanced squamous cell carcinoma of the head and neck.

机译：局部治疗晚期的头颈部鳞状细胞癌后，贫血对疗效和正常组织毒性的影响。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

PURPOSE: The aims of this analysis were to determine the effect of anaemia on loco-regional control, relapse-free survival, cause-specific survival, overall survival, and acute and late radiation therapy toxicity in patients with Stage III and IV squamous cell carcinoma of the head and neck treated with radiotherapy.PATIENTS AND METHODS: Between 1991 and 1998, 350 patients were randomly assigned to either conventional radiotherapy, (70 Gy in 35 fractions in 49 days) or to accelerated radiotherapy (59.4 Gy in 33 fractions in 24 days). Patients were divided into two groups according to their haemoglobin level: a normal haemoglobin group (>/=13 g/dl in males, >/=12 g/dl in females) and a low haemoglobin group (<13 g/dl in males, <12 g/dl in females). The influence of anaemia on cause-specific survival and the development of confluent mucositis independent of other variables was tested using Cox proportional hazards model.RESULTS: Of 350 patients recruited to the trial, 238 had haemoglobin measurements andwere eligible for inclusion in this secondary analysis. One hundred and ninety-three were considered to have normal haemoglobin, and 45 patients were considered to be anaemic. There were significant differences between the groups in loco-regional control, relapse-free survival, cause-specific survival and overall survival, with hazards ratios of 0.56 (95% confidence interval (CI) 0.34-0.94), 0.57 (95% CI 0.35-0.92), 0.49 (95% CI 0.29-0.85) and 0.43 (95% CI 0.26-0.70) in favour of the normal haemoglobin group. Using Cox proportional hazards modelling, haemoglobin level was a significant predictor of cause-specific survival in addition to disease site, stage, and Eastern Cooperative Oncology Group status. There were no statistically significant differences between the groups in the development of acute or late reactions.CONCLUSION: Significant reductions in loco-regional control, disease-free survival, cause-specific survival and overall survival occur in the presence of anaemia. No significant differences in normal tissue toxicity have been identified in this analysis.
机译：目的：本分析的目的是确定贫血对III和IV期鳞状细胞癌患者局部区域控制，无复发生存，特定原因生存，总体生存以及急性和晚期放射治疗毒性的影响患者和方法：1991年至1998年，将350例患者随机分为常规放疗（49天以35分数分为70 Gy）或加速放疗（24天以33分数分为59.4 Gy）。天）。根据血红蛋白水平将患者分为两组：正常血红蛋白组（男性> / = 13 g / dl，女性> / = 12 g / dl）和低血红蛋白组（男性<13 g / dl） ，雌性<12 g / dl）。使用Cox比例风险模型测试了贫血对特定病因生存和融合黏膜炎发展的影响，而与其他变量无关。结果：在该研究招募的350例患者中，有238例进行了血红蛋白测定，可以纳入该次要分析。 193名血红蛋白正常，其中45名患者贫血。两组在局部区域控制，无复发生存，特定原因生存和总体生存方面存在显着差异，危险比分别为0.56（95％置信区间（CI）0.34-0.94），0.57（95％CI 0.35）。 -0.92），0.49（95％CI 0.29-0.85）和0.43（95％CI 0.26-0.70）支持正常的血红蛋白组。使用Cox比例风险建模，除疾病部位，阶段和东部合作肿瘤小组的状态外，血红蛋白水平是特定原因生存的重要预测指标。急性或晚期反应的发生在两组之间没有统计学上的显着差异。结论：局部贫血的局部区域控制，无病生存，特定原因生存和总体生存显着降低。在此分析中，未发现正常组织毒性的显着差异。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号