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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Long-term results of preoperative intra-arterial doxorubicin combined with neoadjuvant radiotherapy, followed by extensive surgical resection for locally advanced soft tissue sarcomas of the extremities.
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Long-term results of preoperative intra-arterial doxorubicin combined with neoadjuvant radiotherapy, followed by extensive surgical resection for locally advanced soft tissue sarcomas of the extremities.

机译：术前动脉内阿霉素联合新辅助放疗的长期结果，然后广泛手术切除四肢局部晚期软组织肉瘤。

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BACKGROUND AND PURPOSE: In the 1980s a combined modality therapy of intraarterial doxorubicin, neoadjuvant radiotherapy and surgery was initiated at the Groningen University Hospital as a limb-saving treatment for locally advanced, primarily irresectable high-grade soft tissue sarcomas (STS) of the extremities. This study presents the short- and long-term results. PATIENTS AND METHODS: Between 1983 and 1987, 11 patients were treated with intraarterial doxorubicin, preoperative radiotherapy (10 x 3.5 Gy) and surgical resection. Non-radical resections received additional postoperative radiotherapy of 20-30 Gy. RESULTS: The limb-salvage rate was 91%, without local recurrences during a median follow-up of 84 months. Six patients died (55%); five from metastatic disease (45%). There were five long-term survivors with a median follow-up of 10 years. Three patients (60%) suffered serious late complications, resulting in disabilitating limb function. CONCLUSION: Although this approach is feasible as a limb-saving treatment for these unfavorable STS, long-term morbidity is high.
机译：背景与目的：在1980年代，格罗宁根大学医院开始采用动脉内阿霉素，新辅助放疗和外科手术相结合的方式疗法，作为四肢局部晚期，主要不可切除的高级软组织肉瘤（STS）的保肢疗法。 。这项研究提出了短期和长期的结果。患者与方法：1983年至1987年，有11例患者接受了动脉内阿霉素，术前放疗（10 x 3.5 Gy）和手术切除的治疗。非根治性切除术后接受了20-30 Gy的额外放射治疗。结果：肢体抢救率为91％，在84个月的中位随访期间无局部复发。 6例患者死亡（55％）; 5名来自转移性疾病（45％）。有5名长期幸存者，中位随访期为10年。三名患者（60％）患有严重的晚期并发症，导致肢体功能丧失。结论：尽管这种方法对于这些不利的STS可以作为节省肢体的方法是可行的，但长期发病率很高。

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