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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Late course accelerated fractionation in radiotherapy of esophageal carcinoma.
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Late course accelerated fractionation in radiotherapy of esophageal carcinoma.

机译：食管癌放疗的晚期病程加速分级分离。

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摘要

PURPOSE: To evaluate the efficacy of adding accelerated fractionation after completing two thirds of routine fractionated radiotherapy in esophageal carcinoma. METHODS AND MATERIALS: From April 1988 to April 1990, 85 patients with histologically confirmed carcinoma of the esophagus were randomized into two groups. (1) The conventional fractionation (CF) group, received 1.8 Gy per day five times a week to a total dose of 68.4 Gy in 7-8 weeks, and (2) the late course accelerated hyperfractionated (LCAF) group which received the same schedule as the CF group during the first two thirds of the course of radiotherapy to a dose of 41.4 Gy/23 fx/4 to 5 weeks. This was then followed by accelerated hyperfractionation using reduced fields. In the LCAF portion of the radiotherapeutic course, the irradiation schedule was changed to 1.5 Gy twice a day, with an interval of 4 h between fractions, to a dose of 27 Gy/18 fx. Thus the total dose was also 68.4 Gy, the same as the CF group, but the course of radiotherapy was shorter, being only 6.4 weeks. The same Cobalt 60 teletherapy unit was used to treat all the cases. RESULTS: The 5 year actuarial survival and disease-free survival rates in the LCAF group were 34% and 42%, as compared to 15% and 15% respectively in the CF group, all statistically significant. Better local control was seen in the LCAF group than in the CF group, the 5 year control rates being 55% versus 21% (P = 0.003). The acute reactions were increased but acceptable in the LCAF patients, the radiation treatments could be completed without any breaks. The late reactions as observed after 5 years were not increased in comparison with the CF patients. CONCLUSIONS: The results from this study show that the late course accelerated hyperfractionated radiotherapy regime can improve results in esophageal carcinoma, with acceptable acute reactions as compared to conventional radiotherapy.
机译：目的：评估在完成三分之二的常规分割放疗后在食管癌中增加加速分割的疗效。方法和材料：从1988年4月至1990年4月，将85例经组织学证实的食道癌患者随机分为两组。 （1）常规分级（CF）组，每天接受1.8 Gy，一周五次，在7-8周内的总剂量为68.4 Gy，（2）晚期加速超分级（LCAF）组，接受相同的剂量在放疗过程的前三分之二期间，将CF组安排为41.4 Gy / 23 fx / 4至5周的剂量。然后使用缩小的场加速超分割。在放射治疗过程的LCAF部分中，每天两次将辐照时间表更改为1.5 Gy，各部分之间的间隔为4 h，剂量为27 Gy / 18 fx。因此，总剂量也为68.4 Gy，与CF组相同，但是放疗的过程更短，仅为6.4周。使用相同的Cobalt 60远程治疗装置治疗所有病例。结果：LCAF组的5年精算生存率和无病生存率分别为34％和42％，而CF组分别为15％和15％，均具有统计学意义。与CF组相比，LCAF组的局部控制效果更好，五年控制率分别为55％和21％（P = 0.003）。急性反应增加，但在LCAF患者中可以接受，放射治疗可以不间断地完成。与CF患者相比，5年后观察到的晚期反应没有增加。结论：这项研究的结果表明，晚期加速超分割放疗方案可以改善食管癌的疗效，与常规放疗相比具有可接受的急性反应。

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