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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Modulation of accelerated repopulation in mouse skin during daily irradiation.
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Modulation of accelerated repopulation in mouse skin during daily irradiation.

机译：每天照射期间小鼠皮肤中加速再填充的调节。

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BACKGROUND AND PURPOSE: The timing of acceleration of repopulation in the epidermis during daily irradiation is related to the development of skin erythema and epidermal hypoplasia. Therefore, the relationship between impairment of the epidermal barrier function, the dermal inflammatory response and epidermal hypoplasia with the acceleration of repopulation was investigated. MATERIALS AND PURPOSE: Skin fields of approximately 1 cm2 on the thighs of TUC mice were given five daily fractions of 3 Gy in each week followed by top-up doses at the end of the first, the second, or the third week to determine residual epidermal tolerance and to calculate repopulation rates in weeks 1, 2, or 3. Systemic modulation of repopulation was attempted by daily indomethacine during fractionated irradiation whereas tape stripping or UV-B exposure before the start of fractionated irradiation attempted local modulation. In parallel experiments, the water permeability coefficient of the epidermis was determined ex vivo by studying transepidermal transport of tritiated water. RESULTS: Without modulation, no repopulation was found in the first week of daily fractionation but repopulation compensated 30% of the dose given in week two and 70% of the dose given in week three. Only tape stripping before the start of fractionated irradiation accelerated repopulation in week one. UV-B had no effect on repopulation although it stimulated proliferation as much as tape stripping. Indomethacin did not suppress acceleration of repopulation. A significant increase in transepidermal water loss was found but only after repopulation had already accelerated. CONCLUSIONS: Acceleration of repopulation in mouse epidermis during daily-fractionated irradiation is not related to the simultaneous development of an inflammatory response. Also, the loss of the epidermal barrier function is not involved in the development of the acceleration response, which rather seems to be triggered directly by the decreased cellularity of the epidermis.
机译：背景与目的：每天照射期间表皮中人口重新聚集的加速时间与皮肤红斑和表皮发育不全的发生有关。因此，研究了表皮屏障功能受损，皮肤炎症反应和表皮发育不全与人口增长加速之间的关系。材料与目的：每周给TUC小鼠大腿上约1 cm2的皮肤区域每天5次，每次3 Gy，然后在第一，第二或第三周结束时补充剂量，以确定残留量表皮耐受性并计算第1、2或3周的再填充率。在分次照射过程中，每天使用吲哚美辛尝试进行系统的再种群调节，而在分次照射开始之前进行胶带剥离或UV-B暴露尝试进行局部调节。在平行实验中，通过研究tri化水的经表皮运输，离体确定表皮的透水系数。结果：未经调节，在每日分级分离的第一周内未发现再种群，但再种群补偿了第二周给予的剂量的30％和第三周给予的剂量的70％。仅在分段照射开始之前剥离胶带会加速第一周的种群重新聚集。尽管UV-B刺激了剥离带的作用，但它对繁殖没有影响。消炎痛并没有抑制人口增长。发现经表皮水分流失显着增加，但仅在重新种群加速之后。结论：每日小幅照射期间小鼠表皮中种群的加速与炎症反应的同时发展无关。同样，表皮屏障功能的丧失不参与加速反应的发展，而加速反应似乎是直接由表皮细胞减少引起的。

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