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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Immediate or delayed radiotherapy in advanced non-small cell lung cancer (NSCLC)? Data from a prospective randomised study.
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Immediate or delayed radiotherapy in advanced non-small cell lung cancer (NSCLC)? Data from a prospective randomised study.

机译：晚期非小细胞肺癌（NSCLC）立即或延迟放疗？来自前瞻性随机研究的数据。

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摘要

BACKGROUND AND PURPOSE: To compare the course of symptoms and health-related quality-of-life (HRQOL) after immediate thoracic radiotherapy (TRT) between symptomatic (S) and non-symptomatic (NS) patients with advanced NSCLC. PATIENTS AND METHODS: 407 stage III/IV patients were initially treated with immediate TRT within a randomised phase III trial comparing different fractionation schedules. At inclusion, patients were prospectively stratified according to presence (S) or absence (NS) of tumour-related chest/airway symptoms to facilitate comparison between these groups. The EORTC QLQ-C30 and LC-13 were used for symptom and HRQOL assessments at baseline and at regular intervals up to 1 year (N=395). RESULTS: NS patients had significantly more favourable baseline characteristics when compared to S patients with a median survival of 11.8 versus 6.0 months (P<0.0001), respectively. At baseline, S patients demonstrated HRQOL scores inferior to those of NS patients (P<0.01) for most scales. Until week 14, NSpatients developed more symptoms while S patients experienced symptom relief in most scales. After week 14, no significant differences could be observed between the groups. CONCLUSION: This study indicates that immediate TRT, given to patients with minimalone chest symptoms, does not prevent development of disease-related symptoms and diminished HRQOL. A wait-and-see policy appears to be acceptable.
机译：背景与目的：比较有症状（S）和无症状（NS）的晚期NSCLC患者在接受立即胸腔放疗（TRT）后的症状和与健康相关的生活质量（HRQOL）。患者与方法：在随机比较不同分级方案的III期随机试验中，最初对407名III / IV期患者进行了即时TRT治疗。纳入时，将根据与肿瘤相关的胸部/气道症状的存在（S）或不存在（NS）对患者进行前瞻性分层，以促进这些组之间的比较。 EORTC QLQ-C30和LC-13在基线和长达1年的固定间隔内用于症状和HRQOL评估（N = 395）。结果：NS患者的基线特征明显优于S患者，中位生存期分别为11.8和6.0个月（P <0.0001）。基线时，在大多数量表上，S患者的HRQOL评分均次于NS患者（P <0.01）。直到第14周，NS病人出现更多症状，而S病人在大多数范围内症状缓解。第14周后，两组之间未观察到明显差异。结论：这项研究表明，对胸部症状极轻/无症状的患者进行即时TRT不能预防疾病相关症状的发展和HRQOL的降低。观望政策似乎是可以接受的。

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