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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >A prospective phase II study of adjuvant postoperative radiation therapy following nodal surgery in malignant melanoma-Trans Tasman Radiation Oncology Group (TROG) Study 96.06.
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A prospective phase II study of adjuvant postoperative radiation therapy following nodal surgery in malignant melanoma-Trans Tasman Radiation Oncology Group (TROG) Study 96.06.

机译：恶性黑色素瘤淋巴结转移术后辅助放疗的前瞻性II期研究-Trans Tasman放射肿瘤学小组（TROG）研究96.06。

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BACKGROUND: The role of adjuvant postoperative therapy after resection of localised malignant melanoma involving regional lymph nodes remains controversial. There are no randomised trials that confirm that postoperative radiation conveys a benefit in terms of regional control or survival. METHODS: Two hundred and thirty-four patients with melanoma involving lymph nodes were registered on a prospective study to evaluate the effect of postoperative radiation therapy. The regimen consisted of 48Gy in 20 fractions to the nodal basin using recommended treatment guidelines for each of the major node sites. The primary endpoints were regional in-field relapse and late toxicity. Secondary endpoints were adjacent relapse, distant relapse, overall survival, progression-free survival and time to in-field progression. RESULTS: Adjuvant radiation therapy was well tolerated by all of the patients. As the first site of relapse, regional in-field relapses occurred in 16/234 patients (6.8%). The overall survival was 36% at 5 years. The progression-free survival and regional control rates were 27% and 91%, respectively, at 5 years. Patients with more than 2 nodes involved had a significantly worse outcome in terms of distant relapse, overall and progression-free survival. CONCLUSION: We believe that adjuvant radiation therapy following nodal surgery could offer a possible benefit in terms of regional control. These results require confirmation in a randomised trial.
机译：背景：局部淋巴结肿大的局部恶性黑色素瘤切除术后辅助治疗的作用仍存在争议。没有随机试验证实术后放疗可带来区域控制或生存方面的益处。方法：对234例涉及淋巴结转移的黑色素瘤患者进行了前瞻性研究，以评估术后放疗的效果。该方案包括按照推荐的治疗指南针对每个主要结节部位，将20个部分的48Gy注入淋巴结。主要终点是区域性田间复发和晚期毒性。次要终点是邻近复发，远处复发，总体生存，无进展生存和到场进展的时间。结果：所有患者对辅助放射治疗的耐受性良好。作为复发的第一个部位，区域内复发发生在16/234位患者中（6.8％）。 5年总生存率为36％。 5年无进展生存率和区域控制率分别为27％和91％。就远处复发，总体生存和无进展生存而言，涉及两个以上淋巴结的患者的预后明显更差。结论：我们认为，结节手术后的辅助放疗可以在区域控制方面提供可能的益处。这些结果需要在随机试验中确认。

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