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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Assessing intra-fractional bladder motion using cine-MRI as initial methodology for Predictive Organ Localization (POLO) in radiotherapy for bladder cancer.
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Assessing intra-fractional bladder motion using cine-MRI as initial methodology for Predictive Organ Localization (POLO) in radiotherapy for bladder cancer.

机译：使用cine-MRI作为膀胱癌放疗中预测器官定位（POLO）的初始方法，评估分数内膀胱运动。

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AIM: To assess the feasibility of using cine-MR to study intra-fractional time-volume and volume-deformity patterns of the bladder during radiotherapy as initial methodology for Predictive Organ Localization (POLO). METHODS: Nine patients receiving radiotherapy for localized muscle invasive bladder cancer were prospectively studied. Each had an MR scan performed on an empty bladder using a T1 weighted cine sequence over a period of 20min. Scans were taken prior to, and repeated towards the end of, radiotherapy treatment. Time-volume sequences were determined and compared before and during radiotherapy. Absolute bladder volumes were then correlated with changes in bladder wall position. RESULTS: The mean post void residual bladder volume prior to radiotherapy at time 0 was 113cm(3) [SD 53] and this did not differ significantly during radiotherapy -106cm [SD 40] (p=0.24, paired t-test analysis). A linear relationship was observed for the rate bladder filling over a 20min period, which did not significantly change on the cine-MR during radiotherapy (regression coefficient 2.1 vs 1.6, respectively, p=0.51). Significant positive relationships were seen between volume and anterior (p=0.02), superior (p<0.001), and inferior (p=0.03) wall motion. These relationships were complex, though linearity was observed for volumes up to 150cm(3). The 1.5cm CTV-PTV margin was sufficient to account for expansion in the majority of cases with the only breach occurring on the anterior wall in one patient. CONCLUSIONS: This study confirms the feasibility of using cine-MR for POLO. The development of such predictive methodology may compensate for the need to use an isotropic CTV-PTV margin to simply cover bladder filling when using image-guided radiotherapy.
机译：目的：评估使用cine-MR作为预测性器官定位（POLO）的初始方法，研究放疗过程中膀胱内分数时间体积和体积变形模式的可行性。方法：前瞻性研究了9例接受放疗的局部性肌肉浸润性膀胱癌患者。每个人在20分钟内使用T1加权电影序列在空膀胱上进行MR扫描。在放疗治疗之前进行扫描，并在放疗结束之前重复进行扫描。在放疗之前和期间确定并比较时间序列。然后将绝对膀胱体积与膀胱壁位置的变化相关。结果：放疗前0时的平均排尿后残余膀胱体积为113cm（3）[SD 53]，而放疗-106cm [SD 40]期间无显着差异（p = 0.24，配对t检验分析）。观察到在20分钟内膀胱充盈率的线性关系，在放疗期间cine-MR上没有明显变化（回归系数分别为2.1对1.6，p = 0.51）。体积与前壁运动（p = 0.02），上壁运动（p <0.001）和下壁运动（p = 0.03）之间存在显着的正相关关系。这些关系很复杂，尽管在最大150cm（3）的体积中观察到线性。 1.5厘米的CTV-PTV边缘足以说明大多数情况下的扩张，其中只有一名患者的前壁破裂。结论：这项研究证实了使用cine-MR治疗POLO的可行性。这种预测方法的发展可能补偿了使用等向性CTV-PTV边缘以覆盖在使用图像引导放射治疗时简单地覆盖膀胱充盈的需求。

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