...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Potential of dose optimisation in MRI-based PDR brachytherapy of cervix carcinoma.
【24h】

Potential of dose optimisation in MRI-based PDR brachytherapy of cervix carcinoma.

机译：在基于MRI的PDR宫颈癌近距离放射治疗中剂量优化的潜力。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND AND PURPOSE: In this study on PDR treatment planning of utero-vaginal carcinoma, we analysed the dosimetry of traditional X-ray based plans as it presents on MR images. The potential gain of MRI-based dose optimisation was assessed. PATIENTS AND METHODS: Sixteen patients boosted with PDR brachytherapy after external beam therapy were included. The clinical X-ray based plans were projected on MR images. The GTV, HR-CTV and IR-CTV were retrospectively contoured, as well as the bladder, rectum and sigmoid colon. The dose in the critical organs and target coverage was investigated. In a second phase, the plans were manually optimised using the MR information. The objectives were to lower the dose in the critical organs (85Gy(alphabeta3) for bladder, 75Gy(alphabeta3) for rectum and sigmoid colon) and to increase the HR-CTV dose to D9085Gy(alphabeta10). RESULTS: In the X-ray based plans, D(2cc) in bladder and sigmoid colon exceeded the tolerance doses in 10/16 and 7/16 patients, respectively. Coverage of the IR-CTV with the 60Gy(alphabeta10) was acceptable. D90 of the HR-CTV was below 85Gy(alphabeta10) in 13 out of 16 patients. After optimisation, the dose constraints in the OAR were not exceeded anymore in any patient. The average D(2cc) dose reduction was 7+/-6Gy(alphabeta3) in the bladder and 7+/-4Gy(alphabeta3) in the sigmoid colon for those patients in which the dose constraint was initially exceeded. In addition, an average dose increase of 3Gy(alphabeta10) was accomplished in the HR-CTV. CONCLUSIONS: MRI-based dose optimisation can play an important role to reduce the dose delivered to the critical organs and to improve target coverage.
机译：背景与目的：在这项关于子宫阴道癌的PDR治疗计划的研究中，我们分析了传统X线检查计划在MR图像上的剂量。评估了基于MRI剂量优化的潜在获益。患者与方法：纳入16例接受外部束治疗后接受PDR近距离放射治疗的患者。基于临床X射线的计划被投影在MR图像上。回顾性地绘制了GTV，HR-CTV和IR-CTV的轮廓，以及膀胱，直肠和乙状结肠的轮廓。研究了关键器官的剂量和目标覆盖率。在第二阶段，使用MR信息手动优化计划。目的是降低关键器官的剂量（膀胱为85Gy（alphabeta3），直肠和乙状结肠为75Gy（alphabeta3）），并将HR-CTV剂量增加至D9085Gy（alphabeta10）。结果：在基于X射线的计划中，膀胱和乙状结肠的D（2cc）分别超过了10/16和7/16患者的耐受剂量。用60Gy（alphabeta10）覆盖IR-CTV是可以接受的。 HR-CTV的D90在16名患者中有13名低于85Gy（alphabeta10）。优化后，任何患者都不再超过OAR中的剂量限制。对于最初超出剂量限制的患者，平均D（2cc）剂量减少在膀胱中为7 +/- 6Gy（alphabeta3），在乙状结肠中为7 +/- 4Gy（alphabeta3）。此外，在HR-CTV中，平均剂量增加了3Gy（alphabeta10）。结论：基于MRI的剂量优化可以在减少传递至关键器官的剂量和改善靶标覆盖率方面发挥重要作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号