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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Preoperative radiotherapy for extremity soft tissue sarcoma; past, present and future perspectives on dose fractionation regimens and combined modality strategies
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Preoperative radiotherapy for extremity soft tissue sarcoma; past, present and future perspectives on dose fractionation regimens and combined modality strategies

机译：术前放射治疗肢体软组织肉瘤;过去，现在和将来对剂量分级方案和组合方式策略的看法

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Introduction: This critical review aims to summarize published data on limb sparing surgery for extremity soft tissue sarcoma in combination with pre-operative radiotherapy (RT). Methods: This review is based on peer-reviewed publications using a PubMed search on the MeSH headings "soft tissue sarcoma" AND "preoperative radiotherapy". Titles and abstracts screened for data including "fraction size AND/OR total dose AND/OR overall treatment time", "chemotherapy", "targeted agents AND/OR tyrosine kinase inhibitors", are collated. Reference lists from some articles have been studied to obtain other pertinent articles. Additional abstracts presented at international sarcoma meetings have been included as well as information on relevant clinical trials available at the ClinicalTrials.gov website. Results: Data are presented for the conventional regimen of 50-50.4 Gy in 25-28 fractions in 5-6 of weeks preoperative external beam RT with respect to the regimen's local control probability compared to surgery alone, as well as acute and late toxicities. The rationale and outcome data for hypofractionated and/or reduced dose regimens are discussed. Finally, combination schedules with conventional chemotherapy and/or targeted agents are summarized. Conclusion: Outside the setting of well-designed prospective clinical trials, the conventional 50 Gy in 5-6 week schedule should be considered as standard. However, current and future studies addressing alternative fraction size, total dose, overall treatment time and/or combination with chemotherapy or targeted agents may reveal regimens of equal or increased efficacy with reduced late morbidities. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
机译：简介：这篇重要的综述旨在总结有关肢体软组织肉瘤合并术前放疗（RT）的肢体保留手术的公开数据。方法：本综述是基于PubMed搜索的MeSH标题“软组织肉瘤”和“术前放疗”进行的同行评审出版物。整理了筛选的标题和摘要，包括“分数大小和/或总剂量和/或总治疗时间”，“化学疗法”，“靶向药物和/或酪氨酸激酶抑制剂”。已经研究了一些文章的参考列表，以获得其他相关文章。还包括在国际肉瘤会议上介绍的其他摘要，以及可在ClinicalTrials.gov网站上获得的有关临床试验的信息。结果：相对于与单独手术相比，该方案的局部控制概率，以及急性和晚期毒性，在术前外束RT的5-6周中以25-28的比例以50-50.4 Gy的常规方案提供了数据。讨论了小剂量和/或减量治疗方案的基本原理和结果数据。最后，总结了与常规化疗和/或靶向药物的联合治疗方案。结论：在设计良好的前瞻性临床试验范围之外，应将常规的5-6周内的50 Gy作为标准治疗。然而，当前和未来的研究涉及替代的分数大小，总剂量，总治疗时间和/或与化学疗法或靶向药物的联合使用，可能显示出疗效相同或提高，晚期发病率降低的方案。 （C）2015 Elsevier Ireland Ltd.保留所有权利。

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