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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Comparison of three accelerated partial breast irradiation techniques: treatment effectiveness based upon biological models.
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Comparison of three accelerated partial breast irradiation techniques: treatment effectiveness based upon biological models.

机译：三种加速的局部乳房照射技术的比较：基于生物学模型的治疗效果。

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BACKGROUND AND PURPOSE: Accelerated partial breast irradiation (APBI) is being studied in a phase III randomized trial as an alternative to whole breast irradiation (WBI) for early stage breast cancer patients. There are three methods for APBI: multi-catheter brachytherapy (MCT), MammoSite brachytherapy (MST), or 3D conformal (3DCRT). There is a paucity of data comparing among methods. Using a linear-quadratic (LQ) model, we evaluated the anticipated efficacy among the APBI methods for equivalent uniform dose (EUD), Tumor Control Probability (TCP), and Normal Tissue Complication Probability (NTCP). MATERIALS AND METHODS: Treatment plans from five patients treated by each APBI modality were retrospectively selected. Dose-volume-histograms (DVH) for planning target volume (PTV), breast, and lung were generated. The LQ parameters alpha=0.3Gy(-1) and alpha/beta=10Gy were used for calculations. The values of EUD, TCP, and NTCP were calculated based on DVHs. RESULTS: The average EUD (normalized to 3.4Gy BID)for the MCT, MST, and 3DCRT APBI was 35, 37.2, and 37.6Gy. When normalized to 2Gy fractionation these become, 42.2, 46.4, and 46.9Gy. Average TCP for MCT, MST, and 3DCRT PBI was 94.8%, 99.1%, and 99.2%. The NTCP values for breast and lung were low for all three methods. CONCLUSIONS: The EUD for PTV and TCP were most similar in MST and 3DCRT APBI and were lower in MCT APBI. This questions the equivalence of the three APBI modalities that are currently being evaluated in the NSABP-B39/RTOG 0413 protocol.
机译：背景与目的：一项针对部分早期乳腺癌患者的加速全乳照射（WBI）的替代方案正在III期随机试验中进行研究。 APBI有三种方法：多导管近距离放射治疗（MCT），MammoSite近距离放射治疗（MST）或3D适形放射（3DCRT）。方法之间的数据比较少。使用线性二次（LQ）模型，我们评估了APBI方法在等效均匀剂量（EUD），肿瘤控制概率（TCP）和正常组织并发症概率（NTCP）之间的预期疗效。材料与方法：回顾性选择5种采用每种APBI方式治疗的患者的治疗计划。生成用于规划目标体积（PTV），乳房和肺部的剂量体积直方图（DVH）。 LQ参数alpha = 0.3Gy（-1）和alpha / beta = 10Gy用于计算。根据DVH计算EUD，TCP和NTCP的值。结果：MCT，MST和3DCRT APBI的平均EUD（标准化为3.4Gy BID）为35、37.2和37.6Gy。当归一化为2Gy分级时，它们变为42.2、46.4和46.9Gy。 MCT，MST和3DCRT PBI的平均TCP为94.8％，99.1％和99.2％。对于这三种方法，乳房和肺的NTCP值均较低。结论：PTV和TCP的EUD在MST和3DCRT APBI中最为相似，而在MCT APBI中较低。这质疑了目前正在NSABP-B39 / RTOG 0413协议中评估的三种APBI模式的等效性。

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