...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >A randomised controlled trial of intervention site radiotherapy in malignant pleural mesothelioma.
【24h】

A randomised controlled trial of intervention site radiotherapy in malignant pleural mesothelioma.

机译：恶性胸膜间皮瘤介入治疗放疗的随机对照试验。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND AND PURPOSE: To assess the effectiveness of radiotherapy in preventing tumour seeding after chest drain or pleural biopsy in patients with malignant mesothelioma and to determine, if tract metastases appear, whether they are tender or troublesome to patients. PATIENTS AND METHODS: Patients with a histological diagnosis of pleural mesothelioma and an invasive procedure within the preceding 21 days were stratified by age, performance status and treatment centre. Randomisation was performed between immediate drain site radiotherapy 21Gy in three fractions (XRT arm) or best supportive care (BSC) with follow-up to 12 months. Patients were asked to complete questionnaires on treatment toxicity and on symptoms from any tract metastases detected. RESULTS: Sixty-one patients were recruited from two centres between 1998 and 2004; 56 men, 5 women, median age 70. 31 were allocated to drain site radiotherapy. Seven patients developed tract metastases associated with the drain site (four XRT arm, three BSC) and four developed metastases associated with subsequent procedures at other sites (three XRT, one BSC). Two patients each developed two tract metastases. Of the 12 metastases, nine overlay the previous drain site but three were adjacent to the site. No statistically significant difference was found in the risk of tract metastasis associated with the drain site between the arms (p=0.748). CONCLUSIONS: Prophylactic drain site radiotherapy in malignant pleural mesothelioma does not reduce the incidence of tumour seeding by the margin indicated by previous studies.
机译：背景与目的：评估放射治疗在预防恶性间皮瘤患者胸腔引流或胸膜穿刺活检后肿瘤播种的有效性，并确定是否出现道转移，是否对患者造成压痛或麻烦。患者和方法：在前21天内对组织学确诊为胸膜间皮瘤并进行了侵入性手术的患者按年龄，表现状态和治疗中心进行分层。随机分组在三个部分的立即引流部位放疗21Gy（XRT组）或最佳支持治疗（BSC）之间进行，随访期为12个月。要求患者填写有关治疗毒性和发现的任何道转移症状的问卷。结果：1998年至2004年期间，从两个中心招募了61名患者; 56名男性，5名女性，中位年龄为70岁。31名被分配到排水部位放疗。 7名患者发生了与引流部位相关的道转移（4个XRT臂，3个BSC），另外4个发展了与其他部位的后续手术相关的转移（3个XRT，1个BSC）。两名患者各发生两个道转移。在12处转移灶中，有9处覆盖了先前的引流部位，但3处与该部位相邻。与两臂间引流部位相关的发生转移的风险没有统计学上的显着差异（p = 0.748）。结论：恶性胸膜间皮瘤的预防性引流部位放疗不能降低以往研究表明的播种率。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号