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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Biological effect of intermittent radiation exposure in vivo: Recovery from sublethal damage versus reoxygenation.
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Biological effect of intermittent radiation exposure in vivo: Recovery from sublethal damage versus reoxygenation.

机译：体内间歇性辐射暴露的生物效应：从亚致死性损伤与复氧中恢复。

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摘要

PURPOSE: In vivo effects of intermittent irradiation are influenced by recovery from sublethal damage (SLDR) and reoxygenation, so contribution of the two factors were investigated using murine tumors. METHODS AND MATERIALS: 1-cm-diameter SCCVII tumors growing in the legs of C3H/HeN mice were used. First, effects of 5 fractions of 6Gy given at intervals of 2.5-15min were compared using an in vivo-in vitro assay, by clamping the tumor-bearing legs to exclude the influence of reoxygenation. In the second and third experiments, changes in the hypoxic fraction at 0-15min after 13 or 5Gy were assessed by a paired cell survival method. Fourth, effects of 5 fractions of 5Gy given at intervals of 3-10min under conditions of limited reoxygenation were compared using a growth delay assay. RESULTS: Cell survival from clamped tumors tended to increase with elongation of the intervals, but not significantly. The hypoxic fraction tended to decrease at 5-15min from the level immediately after irradiation. Effects on tumor growth tended to decrease with elongation of the intervals. CONCLUSIONS: Reoxygenation occurring within 5-15min appeared to compensate for SLDR in SCCVII tumors. When reoxygenation was limited, the decrease of radiation effect occurred due to SLDR.
机译：目的：间歇性辐射的体内效应受亚致死损伤（SLDR）和复氧的恢复的影响，因此使用鼠类肿瘤研究了这两个因素的作用。方法和材料：使用在C3H / HeN小鼠腿部生长的直径为1厘米的SCCVII肿瘤。首先，使用体内-体外试验，通过夹紧荷瘤的腿以排除复氧的影响，比较了以2.5-15min的间隔给予的5Gys的5个部分的效果。在第二和第三次实验中，通过配对细胞存活方法评估了13或5Gy后0-15分钟的低氧分数的变化。第四，使用生长延迟试验比较了在有限的复氧条件下以3-10分钟的间隔给予的5Gy的5馏分的效果。结果：受钳制肿瘤的细胞存活率随着间隔时间的延长而增加，但没有明显的增加。低氧分数倾向于在辐照后立即从水平降低5-15分钟。随着时间间隔的延长，对肿瘤生长的影响倾向于降低。结论：5-15分钟内发生的复氧似乎可以补偿SCCVII肿瘤中的SLDR。当限制复氧时，由于SLDR导致了辐射效应的降低。

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