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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Radiation dose associated with local control in advanced anal cancer: retrospective analysis of 129 patients.
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Radiation dose associated with local control in advanced anal cancer: retrospective analysis of 129 patients.

机译：晚期肛门癌局部放疗的放射剂量：129例患者的回顾性分析。

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摘要

BACKGROUND AND PURPOSE: To retrospectively analyse a large consecutive cohort of patients with anal cancer for treatment-related factors influencing local control and survival. MATERIALS AND METHODS: All patients referred for primary radiotherapy at Medical University of Vienna in 1990-2002 with anal canal carcinoma without distant metastases were analysed. Treatment consisted of external radiotherapy with or without brachytherapy and with or without chemotherapy. Patient-, tumour-, and treatment-factors were tested for influence on survival and local control using Cox multivariate analysis. RESULTS: Median age was 67 years (n=129), the UICC stage distribution was 15%, 58%, and 27% for stages I, II, and III, respectively. With median follow-up of 8.0 years for surviving patients (3.9 years including deceased patients), five-year overall survival and disease-free-survival were 57% and 51%, respectively. Local control at 5 years was 87%. Stage and age were significant factors for overall and colostomy-free-survival, N-stage for disease-free-survival. Shorter overall treatment time favoured local control in stage T1-2 (p=.015), higher total radiation dose and female gender were associated with improved local control in T3-4 tumours (p=.021). CONCLUSIONS: These results support potential improvement of anal cancer treatment by studying advanced technology such as IMRT, making it possible to tailor high-dose regions.
机译：背景与目的：回顾性分析一大批连续性肛门癌患者的治疗相关因素，这些因素影响局部控制和生存。材料与方法：分析所有1990-2002年在维也纳医科大学就诊的原发性放疗的无远处转移的肛管癌患者。治疗包括有或没有近距离放疗以及有或没有化疗的外部放疗。使用Cox多变量分析测试了患者，肿瘤和治疗因素对生存和局部控制的影响。结果：中位年龄为67岁（n = 129），I，II和III期的UICC分期分别为15％，58％和27％。幸存患者的中位随访时间为8.0年（包括死者为3.9年），五年总生存率和无病生存率分别为57％和51％。 5年的本地控制率为87％。阶段和年龄是总体和无结肠造口生存的重要因素，N阶段是无疾病生存的重要阶段。较短的总体治疗时间有利于在T1-2期进行局部控制（p = .015），较高的总放射剂量和女性性别与改善的T3-4肿瘤局部控制相关（p = .021）。结论：这些结果通过研究先进的技术（例如IMRT），支持对肛门癌治疗的潜在改进，从而可以调整高剂量区域。

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