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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Short-course radiotherapy, with elective delay prior to surgery, in patients with unresectable rectal cancer who have poor performance status or significant co-morbidity.
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Short-course radiotherapy, with elective delay prior to surgery, in patients with unresectable rectal cancer who have poor performance status or significant co-morbidity.

机译：对于表现状态差或合并症严重的无法切除的直肠癌患者，术前应选择短期治疗进行短程放疗。

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BACKGROUND AND PURPOSE: Standard treatment for rectal cancer which threatens the expected plane of resection on MRI imaging is long-course, pre-operative chemoradiotherapy (1.8-2Gy, 25-28 fractions). Not all patients are suitable for this because of age, poor performance status or co-morbidities. We describe our experience of short-course (5x5Gy) pre-operative radiotherapy with planned, delayed surgery (SCPRT-delay) in this patient group. MATERIALS AND METHODS: Between April 2001 and October 2007, 43 patients were selected for SCPRT-delay. The clinical records were retrospectively evaluated. RESULTS: Median age was 82 (range 58-87). Forty-one patients had radiotherapy of which 26 (61%) were subsequently able to have surgery. Of these, R0, R1 and R2 resections were performed in 22, 2 and 2 patients, respectively. Treatment was well tolerated, although two patients required hospital admission for management of diarrhoea and one developed significant late small bowel toxicity, attributable to radiotherapy. In those undergoing R0 or R1 resection there have been no local recurrences (median follow-up 18 months). Median survival for the whole group was 23 months, although this was 44 months in those undergoing surgery. CONCLUSIONS: SCPRT-delay appears to be a useful alternative to long-course pre-operative chemoradiotherapy in this high-risk group of patients.
机译：背景与目的：直肠癌的标准治疗方法是长期，术前放化疗（1.8-2Gy，25-28级），这可能威胁到MRI预期的切除平面。由于年龄，性能状况差或合并症，并非所有患者都适合此。我们描述了该患者组中的短期（5x5Gy）术前放疗与计划的，延迟的手术（SCPRT延迟）的经验。材料与方法：2001年4月至2007年10月，选择了43例进行SCPRT延迟治疗的患者。对临床记录进行回顾性评估。结果：中位年龄为82岁（范围58-87）。 41名患者接受了放射治疗，其中26名（61％）随后接受了手术治疗。其中，分别在22、2和2例患者中进行了R0，R1和R2切除。尽管有2位患者需要住院以治疗腹泻，并且1位患者因放疗而出现明显的晚期小肠毒性，但治疗耐受性良好。在接受R0或R1切除的患者中，没有局部复发（中位随访18个月）。整个组的中位生存期为23个月，而接受手术的患者中位生存期为44个月。结论：在这种高风险患者中，SCPRT延迟似乎是长程术前放化疗的有效替代方法。

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