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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Correlation between dose to the pharyngeal constrictors and patient quality of life and late dysphagia following chemo-IMRT for head and neck cancer.
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Correlation between dose to the pharyngeal constrictors and patient quality of life and late dysphagia following chemo-IMRT for head and neck cancer.

机译：头颈癌化学IMRT后咽喉收缩剂量与患者生活质量和晚期吞咽困难之间的相关性。

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PURPOSE: Aim of this study was to correlate dose to pharyngeal constrictors (PC) with subjective and observer-based assessments of swallowing in patients with head and neck cancer undergoing concomitant chemo-IMRT. MATERIALS AND METHODS: Dose-volume histograms (DVHs) for superior constrictor (SC), middle constrictor (MC) and inferior constrictor (IC) were generated for 37 patients. Mean doses to SC, MC and IC were correlated to objective dysphagia grade (1 year, RTOG scoring) and global, total physical (TP) and most relevant components of the physical section (P6, P8) of the MD Anderson dysphagia inventory (MDADI) which was evaluated post-treatment. Odds ratios of dysphagia (>grade 0), poor global (<3), TP (<32), P6 (<3) and P8 (<3) for patients with mean dose>60 Gy to SC and IC were calculated. RESULTS: There was no significant correlation between mean dose to PC and any of the analysed MDADI parameters and observer-assessed dysphagia grade. Odds ratio of dysphagia (>grade 0), poor global (<3), TP (<32), P6 (<3) and P8 (<3) for patients with mean dose>60 Gy to IC and SC were not significantly higher than those for patients receiving <60 Gy. CONCLUSION: This study did not find a statistically significant correlation between radiation dose to the PC and observer-assessed dysphagia grade or patient-reported MDADI questionnaire at 1 year.
机译：目的：本研究的目的是将咽收缩器（PC）的剂量与接受化学IMRT化疗的头颈癌患者的吞咽的主观和基于观察者的评估联系起来。材料与方法：生成了37例上缩血管（SC），中缩血管（MC）和下缩血管（IC）的剂量-体积直方图（DVH）。 SC，MC和IC的平均剂量与客观吞咽困难等级（1年，RTOG评分）以及MD安德森吞咽困难清单（MDADI）的物理部分的整体，总体质（TP）和最相关成分（P6，P8）相关）进行了后处理评估。计算平均剂量> 60 Gy的SC和IC患者吞咽困难（> 0级），整体不良（<3），TP（<32），P6（<3）和P8（<3）的几率。结果：PC平均剂量与任何分析的MDADI参数和观察者评估的吞咽困难程度之间无显着相关性。对于IC和SC平均剂量> 60 Gy的患者，吞咽困难（> 0级），总体不良（<3），TP（<32），P6（<3）和P8（<3）的几率没有明显升高比接受<60 Gy的患者要高。结论：本研究未发现PC的辐射剂量与观察者评估的吞咽困难等级或患者在1年时报告的MDADI问卷之间有统计学意义的相关性。

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