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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >GTV spatial conformity between different delineation methods by 18FDG PET/CT and pathology in esophageal cancer.
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GTV spatial conformity between different delineation methods by 18FDG PET/CT and pathology in esophageal cancer.

机译：食管癌中18FDG PET / CT的不同划界方法与病理之间的GTV空间一致性。

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摘要

PURPOSE: To find optimal threshold of length and GTV delineation for esophageal cancer using 18FDG PET/CT. MATERIALS AND METHODS: Sixteen patients with esophageal carcinoma underwent surgery. For each patient, six GTVs were defined. GTVCT was based on CT data alone. GTV20%, GTV40%, GTV2.5 and GTV40%M were generated by PET/CT, using SUVbgd + 20%(SUVmax(slice)--SUVbgd), SUVbgd + 40%(SUVmax(slice)--SUVbgd), 2.5 and 40%SUVmax(total) as thresholds. GTVpath was derived from pathology. Lengths of GTVs were recorded as LCT, L20%, L40%, L2.5, L40%M and Lpath, respectively. The former five GTVs/lengths were compared with GTVpath/Lpath by means of a conformity index CI/CI', which is the square of intersection of two GTVs/lengths divided by their product. RESULTS: Mean LCT, L20%, L40%, L2.5, L40%M and Lpath were 6.30 +/- 2.69, 5.55 +/- 2.48, 6.80 +/- 2.92, 6.65 +/- 2.66, 4.88 +/- 1.99 and 5.90 +/- 2.38 cm. Mean , , , and were 0.68 +/- 0.16, 0.84 +/- 0.17, 0.76 +/- 0.14, 0.78 +/- 0.15 and 0.80 +/- 0.11. and was significantly superior to (P < 0.05). Mean GTVCT, GTV20%, GTV40%, GTV2.5, GTV40%M and GTVpath were 29.16 +/- 18.56, 18.75 +/- 12.37, 12.52 +/- 8.08, 22.69 +/- 14.84, 9.18 +/- 5.96 and 28.16 +/- 17.02 cm3. Mean CIs increased significantly from CI40%&path(0.27 +/- 0.09) and CI'40% M&path (0.28 +/- 0.08) < CI'20% & path (0.52 +/- 0.16) and CI'2.5&path (0.52 +/- 0.20) < CICT&path(0.77 +/- 0.17). CONCLUSIONS: The SUVbgd + 20% (SUVmax(slice)--SUVbgd) method optimally estimated gross tumor length, but only reached an unsatisfactory CI for GTV. Due to possible motion factor enveloped in PET images and lack of histopathologic transverse reference, the information from both PET and CT should be referred to complementarily when delineating GTV.
机译：目的：使用18FDG PET / CT查找食管癌的最佳长度和GTV轮廓。材料与方法：16例食管癌患者接受了手术治疗。为每位患者定义了六个GTV。 GTVCT仅基于CT数据。 PET / CT产生的GTV20％，GTV40％，GTV2.5和GTV40％M使用SUVbgd + 20％（SUVmax（slice）-SUVbgd），SUVbgd + 40％（SUVmax（slice）-SUVbgd），2.5和40％SUVmax（总计）作为阈值。 GTVpath源自病理学。 GTV的长度分别记录为LCT，L20％，L40％，L2.5，L40％M和Lpath。通过一致性指数CI / CI'将前五个GTV /长度与GTVpath / Lpath进行比较，该指数是两个GTV /长度的交点的平方除以其乘积。结果：平均LCT，L20％，L40％，L2.5，L40％M和Lpath为6.30 +/- 2.69、5.55 +/- 2.48、6.80 +/- 2.92、6.65 +/- 2.66、4.88 +/- 1.99和5.90 +/- 2.38厘米。均值，，和为0.68 +/- 0.16、0.84 +/- 0.17、0.76 +/- 0.14、0.78 +/- 0.15和0.80 +/- 0.11。并且显着优于（P <0.05）。平均GTVCT，GTV20％，GTV40％，GTV2.5，GTV40％M和GTVpath为29.16 +/- 18.56、18.75 +/- 12.37、12.52 +/- 8.08、22.69 +/- 14.84、9.18 +/- 5.96和28.16 +/- 17.02立方厘米。平均CI从CI40％＆path（0.27 +/- 0.09）和CI'40％M＆path（0.28 +/- 0.08）

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