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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Applicator reconstruction in MRI 3D image-based dose planning of brachytherapy for cervical cancer.
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Applicator reconstruction in MRI 3D image-based dose planning of brachytherapy for cervical cancer.

机译：子宫颈癌近距离放射治疗基于MRI 3D图像的剂量规划中的涂药器重建。

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BACKGROUND AND PURPOSE: To elaborate a method for applicator reconstruction for MRI-based brachytherapy for cervical cancer. MATERIALS AND METHODS: Custom-made plastic catheters with a copper sulphate solution were made for insertion in the source channels of MR-CT compatible applicators: plastic and titanium tandem ring applicators, and titanium needles. The applicators were CT and MR scanned in a phantom for accurate 3D assessment of applicator visibility and geometry. A reconstruction method was developed and evaluated in 19 patient MR examinations with ring applicator (plastic: 14, titanium: 5). MR applicator reconstruction uncertainties related to inter-observer variation were evaluated. RESULTS: The catheters were visible in the plastic applicator on T1-weighted images in phantom and in 14/14 clinical applications. On T2-weighted images, the catheters appeared weaker but still visible in phantom and in 13/14 MR clinical applications. In the titanium applicator, the catheters could not be separated from the artifacts from the applicator itself. However, these artifacts could be used to localize both titanium ring applicator (5/5 clinical applications) and needles (6/6 clinical applications). Standard deviations of inter-observer differences were below 2 mm in all directions. CONCLUSION: 3D applicator reconstruction based on MR imaging could be performed for plastic and titanium applicators. Plastic applicators proved well to be suited for MRI-based reconstruction. For improved practicability of titanium applicator reconstruction, development of MR applicator markers is essential. Reconstruction of titanium applicator and needles at 1.5 T MR requires geometric evaluations in phantoms before using the applicator in patients.
机译：背景和目的：阐述一种用于基于子宫颈癌的基于MRI的近距离放射治疗的涂药器重建方法。材料与方法：制作了带有硫酸铜溶液的定制塑料导管，用于插入MR-CT兼容敷贴器的源通道：塑料和钛串联环敷贴器以及钛针。以幻影方式对涂药器进行CT和MR扫描，以对涂药器的可见性和几何形状进行精确的3D评估。开发了一种重建方法，并用环涂器（塑料：14，钛：5）在19位患者的MR检查中进行了评估。评估了与观察者间差异相关的MR涂药器重建不确定性。结果：在幻影的T1加权图像和14/14临床应用中，塑料涂药器中可见导管。在T2加权图像上，导管显得较弱，但在幻影和13/14 MR临床应用中仍可见。在钛涂药器中，导管无法与涂药器本身的伪影分开。但是，这些伪影可用于定位钛环施用器（5/5临床应用）和针头（6/6临床应用）。观察者间差异的标准偏差在所有方向上均小于2 mm。结论：基于MR成像的3D涂药器可用于塑料和钛制涂药器。事实证明，塑料涂药器非常适合基于MRI的重建。为了提高钛施药器重建的实用性，开发MR施药器标记至关重要。于1.5 T MR重建钛制涂药器和针头需要在幻影中进行几何评估，然后才能在患者中使用涂药器。

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