...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Anatomical and clinical predictors of acute bowel toxicity in whole pelvis irradiation for prostate cancer with Tomotherapy.
【24h】

Anatomical and clinical predictors of acute bowel toxicity in whole pelvis irradiation for prostate cancer with Tomotherapy.

机译：Tomotherapy对前列腺癌全盆腔照射急性肠毒性的解剖学和临床预测指标。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

PURPOSE: Assessing predictors of acute bowel toxicity after whole-pelvis irradiation (WPRT) Image-guided Tomotherapy with simultaneous integrated boost on prostate/prostate bed. METHODS AND MATERIALS: In the period March 2005-April 2009, 178 patients were treated with radical or adjuvant/salvage intent with WPRT Tomotherapy. Median dose to the pelvic nodes was 51.8 Gy/28 fractions while concomitantly delivering 65.5-74.2 Gy to prostate/prostatic bed. The impact of many anatomical and clinical parameters on >/= Grade 2 acute bowel toxicity was investigated by logistic analyses. RESULTS: Only 15/178 patients (8.4%) experienced Grade 2 toxicity (none Grade 3). Main predictors at univariate analysis were nodal CTV (CTVN >/= 380 cc; OR: 3.7, p=0.017), treatment duration (< 40 days; OR: 6.2, p=0.006) and Grade 2 acute rectal toxicity (OR: 6.5, p=0.015). A multivariate analysis including only pre-treatment variables revealed an independent role of CTVN and age; if including treatment-related factors the best predictors were age, treatment duration and Grade 2 rectal toxicity. This last was correlated with the overlap between PTVN and loops (OVPN >/= 51 cc; OR: 14.4, p=0.0003) that is representative of the volume of loops receiving the prescribed dose (51.8 Gy, 1.85 Gy/fr). CONCLUSIONS: Acute bowel toxicity after WPRT Tomotherapy is mild, relatively rare and associated to larger CTVN and older age. While efforts to further reduce it do not appear to be relevant, the pre-treatment assessment of "high-risk" patients may help physicians in better managing symptoms. A prospective validation would be very important in confirming these results and in better refining dose-volume bowel effects including symptoms milder that the ones here investigated and retrospectively assessed.
机译：目的：评估全骨盆照射（WPRT）图像引导的Tomotherapy并同时在前列腺/前列腺床上同时进行增强治疗后急性肠毒性的预测指标。方法和材料：在2005年3月至2009年4月期间，对178例患者进行了WPRT放射疗法的根治性或辅助/挽救性治疗。盆腔淋巴结的中位剂量为51.8 Gy / 28分数，同时将65.5-74.2 Gy递送至前列腺/前列腺床。通过逻辑分析研究了许多解剖学和临床参数对> / = 2级急性肠毒性的影响。结果：只有15/178名患者（8.4％）经历了2级毒性（无3级）。单因素分析的主要预测指标是结节性CTV（CTVN> / = 380 cc; OR：3.7，p = 0.017），治疗时间（<40天; OR：6.2，p = 0.006）和2级急性直肠毒性（OR：6.5） ，p = 0.015）。仅包括治疗前变量的多变量分析表明，CTVN和年龄具有独立的作用。如果包括治疗相关因素，则最佳预测因素是年龄，治疗持续时间和2级直肠毒性。最后一个与PTVN和环之间的重叠（OVPN> / = 51 cc;或：14.4，p = 0.0003）相关，该重叠代表接受规定剂量（51.8 Gy，1.85 Gy / fr）的环的体积。结论：WPRT Tomotherapy术后的急性肠毒性是轻度的，相对较少，并且与较大的CTVN和年龄较大有关。尽管进一步降低它的努力似乎无关紧要，但对“高风险”患者的治疗前评估可能有助于医生更好地管理症状。前瞻性验证对于确认这些结果以及更好地改善剂量-体积肠效应（包括较此处所研究和回顾的症状较轻的症状）非常重要。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号