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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Is there a relation between the radiation dose to the different sub-segments of the lower urinary tract and urinary morbidity after brachytherapy of the prostate with I-125 seeds?
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Is there a relation between the radiation dose to the different sub-segments of the lower urinary tract and urinary morbidity after brachytherapy of the prostate with I-125 seeds?

机译：用I-125种子对前列腺进行近距离放射治疗后，下尿路不同子段的辐射剂量与尿毒症发病率之间是否有关系？

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Background and Purpose To investigate possible relationships between the dose to the sub-segments of the lower urinary tract and lower urinary tract symptoms (LUTS) after brachytherapy of the prostate. Materials and Methods This study involved 225 patients treated for prostate cancer with I-125 seeds. Post-implant dose-volume histograms of the prostate, urethra, bladder wall, bladder neck and external sphincter were determined. Endpoints were the mean and the maximum International Prostate Symptom Score (IPSS) during the first 3 months after the treatment. For binary analysis the patients were stratified in a group with enhanced LUTS and a group with non-enhanced LUTS. Results The dose to 0.5 cm3 of the bladder neck 'D0.5cc-blne' (p = 0.002 and p = 0.005), the prostate volume prior to treatment 'Vpr-0' (p = 0.005 and p = 0.024) and the pre-treatment IPSS (both p 0.001) were independently correlated with mean and maximum IPSS, respectively. Of the patients with a D0.5cc-blne ≥ 175 Gy and a Vpr-0 ≥ 42 cm3, 68% suffered from enhanced LUTS, against just 30% of the other patients (p 0.0001). Conclusions Pre-treatment IPSS, prostate volume and dose to the bladder neck are correlated with post-implant IPSS. A combination of a large prostate and a high dose to the bladder neck is highly predictive for enhanced early LUTS.
机译：背景与目的探讨前列腺近距离放射治疗后下尿路亚段剂量与下尿路症状（LUTS）之间的可能关系。材料和方法该研究涉及225例接受I-125种子治疗的前列腺癌患者。确定植入后的前列腺，尿道，膀胱壁，膀胱颈和外括约肌的剂量-体积直方图。终点是治疗后前三个月的平均和最大国际前列腺症状评分（IPSS）。为了进行二元分析，将患者分为LUTS增强组和LUTS非增强组。结果到0.5 cm3的膀胱颈'D0.5cc-blne'剂量（p = 0.002和p​​ = 0.005），治疗前的前列腺体积'Vpr-0'（p = 0.005和p = 0.024）和前治疗IPSS（均p <0.001）分别与平均IPSS和最大IPSS相关。 D0.5cc-blne≥175 Gy且Vpr-0≥42 cm3的患者中，有68％的患者患有LUTS升高，而其他患者中只有30％（p <0.0001）。结论治疗前IPSS，前列腺体积和膀胱颈剂量与植入后IPSS相关。大前列腺和膀胱颈高剂量的结合对于提高早期LUTS具有高度的预测性。

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