HSV-1 UL45 encodes a carbohydrate binding C-type lectin protein.

Wyrwicz LS; Ginalski K; Rychlewski L

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HSV-1 UL45 encodes a carbohydrate binding C-type lectin protein.

机译：HSV-1 UL45编码结合碳水化合物的C型凝集素蛋白。

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HSV-1 genome, apart from glycoproteins critical for egress to host cells, encodes several additional membrane proteins. Among them, UL45-a class II protein dispensable for growth in vitro-was recently determined as an important virulence factor of HSV-1 neurotropism. To investigate the molecular mechanism of UL45 activity we applied the state-of-the-art bioinformatic methods for protein structure prediction. Results of this study clearly show that UL45 encodes a C-type lectin fold protein. The identification of a novel potentially targetable domain has direct implications for guiding further research on inhibition of HSV-1 transmission to neural cells by carbohydrate or glycomimetic antagonists.The transmission of virus particles is one of limiting steps of viral life cycle. Viruses utilize common receptors localized on the variety of tissues, but the clinical picture suggests that the associated disease usually affects only the selected types of cells. The selection of the subset of body cells (cell tropism) can be a result of either anatomical barriers or a nature of host-pathogen specific interactions.

机译：HSV-1基因组除了对进入宿主细胞至关重要的糖蛋白外，还编码其他几种膜蛋白。其中，UL45-一种可在体外生长的II类蛋白质-最近被确定为HSV-1神经嗜性的重要毒力因子。为了研究UL45活性的分子机制，我们将最新的生物信息学方法用于蛋白质结构预测。这项研究的结果清楚地表明，UL45编码C型凝集素折叠蛋白。鉴定潜在的新靶标结构域具有直接的指导意义，可指导进一步研究抑制碳水化合物或糖模拟物拮抗剂对HSV-1向神经细胞的传播。病毒颗粒的传播是病毒生命周期的限制性步骤之一。病毒利用位于各种组织上的共同受体，但临床图片表明，相关疾病通常仅影响所选类型的细胞。体细胞亚群的选择（细胞嗜性）可能是解剖学障碍或宿主-病原体特异性相互作用的性质的结果。

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《Cell cycle》 |2008年第2期|共3页
作者
Wyrwicz LS; Ginalski K; Rychlewski L;
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正文语种 eng
中图分类细胞生物学;
关键词
Amino Acid Sequence; Genome; Viral; Herpesvirus 1; Human; Lectins; C-Type;

机译：氨基酸序列;基因组;病毒;疱疹病毒1;人;凝集素;C型;

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1. HSV-1 UL45 encodes a carbohydrate binding C-type lectin protein. [J] . Wyrwicz LS, Ginalski K, Rychlewski L Cell cycle . 2008,第2期

机译：HSV-1 UL45编码结合碳水化合物的C型凝集素蛋白。
2. Alteration of the Carbohydrate-Binding Specificity of a C-type Lectin CEL-I Mutant with an EPN Carbohydrate-Binding Motif [J] . Tomomitsu Hatakeyama, Tomohiro Ishimine, Tomohiro Baba, Protein and peptide letters . 2013,第7期

机译：C型凝集素CEL-1突变体与EPN碳水化合物结合基序的碳水化合物结合特异性的改变
3. Structure and carbohydrate-binding properties of a C-type lectin SPL with novel carbohydrate-recognition motifs [J] . Itakura Shuhei, Unno Hideaki, Goda Shuichiro, Protein Science: A Publication of the Protein Society . 2016,第Suppla1期

机译：具有新型碳水化合物识别基序的C型凝集素SPL的结构和碳水化合物结合特性
4. Fluorophore-labeled, Peptide-based Glycoclusters: Synthesis, Binding Properties for Lectins and Detection of Carbohydrate-binding Proteins in Cells [C] . Xizhe Tian, Jaevoung Pai, Kyung-Hwa Baek International Carbohydrate Symposium . 2013

机译：荧光团标记，基于肽的糖蛋白：合成，凝集素的结合性质和细胞中碳水化合物结合蛋白的检测
5. Binding specificity and recognition roles of the Atlantic salmon serum C-type lectin. [D] . Uribe, Elke. 2010

机译：大西洋鲑血清C型凝集素的结合特异性和识别作用。
6. Carbohydrate Binding Mechanism of the Macrophage Galactose-type C-type Lectin 1 Revealed by Saturation Transfer Experiments [O] . Masayoshi Sakakura, Sarawut Oo-Puthinan, Chifumi Moriyama, 2008

机译：巨噬细胞半乳糖C型的糖结合机理凝集素1通过饱和转移显示实验
7. The Plasminogen Binding Site of the C-Type Lectin Tetranectin Is Located in the Carbohydrate Recognition Domain, and Binding Is Sensitive to Both Calcium and Lysine [O] . Jonas Heilskov Graversen, Rikke Høegh Lorentsen, Christian Jacobsen, 1998

机译：C型凝集素Tetranectin的纤溶酶原结合位点位于碳水化合物识别结构域中，结合对钙和赖氨酸敏感

HSV-1 UL45 encodes a carbohydrate binding C-type lectin protein.

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