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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Displacement of hepatic tumor at time to exposure in end-expiratory-triggered-pulse proton therapy.
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Displacement of hepatic tumor at time to exposure in end-expiratory-triggered-pulse proton therapy.

机译：呼气末触发脉冲质子治疗中暴露时的肝肿瘤移位。

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摘要

PURPOSE: This study is to evaluate reproducibility of hepatic tumors in end-expiration and end-inspiration on free-breathing, also measure shift of hepatic tumor location in pulsed proton beams exposure in end-expiration in order to estimate feasible planning target volume (PTV) margin. MATERIALS AND METHODS: Pairs (1232) of anterior and lateral radiographs from 30 patients (628 end-expiration and 604 end-inspiration phases) were analyzed using fiducial markers adjacent to the tumors. By using the co-ordinates of the marker centroid of mass related to the isocenter, intrafractional variation was compared in end-expiration and end-inspiration, and a feasible PTV margin was generated using the measured motion. RESULTS: The average internal motion in end-expiration was 1.1mm, which was significantly smaller than that in end-inspiration. The mean deviation from the plan was -0.1, 0.3, and 0.1mm in the left-right (LR), cranio-cepharal (CC), and anterior-posterior (AP) directions, respectively. The estimated PTV margins were 3.2, 3.5, and 4.6mm, in the LR, CC, and AP directions, respectively. CONCLUSIONS: It was indicated that localization of the targets was more reproducibility in end-expiration than that in end-inspiration. Also, feasible and practical margin values were obtained. These should contribute accuracy of respiration synchronized proton radiotherapy for liver tumors.
机译：目的：本研究旨在评估自由呼吸的呼气末期和呼气末期肝肿瘤的可再现性，还测量呼气末期脉冲质子束暴露中肝肿瘤位置的偏移，以估算可行的计划目标体积（PTV） ）保证金。材料与方法：使用邻近肿瘤的基准标记物分析了30例患者（628呼气末期和604呼气末期）的前后X线对（1232）。通过使用与等中心点相关的质量标记质心的坐标，比较了呼气末期和呼气末期的分数内变化，并使用测得的运动生成了可行的PTV余量。结果：呼气末的平均内部运动为1.1mm，明显小于呼气末的平均内部运动。与计划的平均偏差在左右（LR），颅脑（CC）和前后（AP）方向分别为-0.1、0.3和0.1mm。在LR，CC和AP方向上，估计的PTV边距分别为3.2mm，3.5mm和4.6mm。结论：表明靶标的定位在最终呼气中比在最终吸气中更可再现。而且，获得了可行的和实际的裕度值。这些应有助于对肝脏肿瘤进行呼吸同步质子放疗。

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