AKT-mediated enhanced aerobic glycolysis causes acquired radioresistance by human tumor cells

Shimura Tsutomu; Noma Naoto; Sano Yui; Ochiai Yasushi; Oikawa Toshiyuki; Fukumoto Manabu; Kunugita Naoki

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AKT-mediated enhanced aerobic glycolysis causes acquired radioresistance by human tumor cells

机译：AKT介导的有氧糖酵解增强导致人类肿瘤细胞获得抗放射性

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Background and purpose: Cellular radioresistance is a major impediment to effective radiotherapy. Here, we demonstrated that long-term exposure to fractionated radiation conferred acquired radioresistance to tumor cells due to ART-mediated enhanced aerobic glycolysis.

机译：背景与目的：细胞放射抗性是有效放射治疗的主要障碍。在这里，我们证明了由于ART介导的有氧糖酵解作用的增强，长期暴露于分馏辐射后会赋予肿瘤细胞抗辐射性。

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《Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology》 |2014年第2期|共6页
作者
Shimura Tsutomu; Noma Naoto; Sano Yui; Ochiai Yasushi; Oikawa Toshiyuki; Fukumoto Manabu; Kunugita Naoki;
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正文语种 eng
中图分类肿瘤学;
关键词
Glycolysis; AKT; Radioresistance; Glut1; 2-Deoxy-D-glucose;

机译：糖酵解;AKT;放射电阻;Glut1;2-脱氧-D-葡萄糖;

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1. AKT-mediated enhanced aerobic glycolysis causes acquired radioresistance by human tumor cells [J] . Shimura Tsutomu, Noma Naoto, Sano Yui, Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology . 2014,第2期

机译：AKT介导的有氧糖酵解增强导致人类肿瘤细胞获得抗放射性
2. Crosstalk of protein kinase C epsilon with Smad2/3 promotes tumor cell proliferation in prostate cancer cells by enhancing aerobic glycolysis [J] . Xu Wanfu, Zeng Fangyin, Li Songyu, Cellular and molecular life sciences: CMLS . 2018,第24期

机译：用Smad2 / 3的蛋白激酶C epsilon串扰通过增强有氧糖醇促进前列腺癌细胞中的肿瘤细胞增殖
3. Inhibition of aerobic glycolysis enhances the anti-tumor efficacy of Zoptarelin Doxorubicin in triple-negative breast cancer cells [J] . Gruendker Carsten, Wokoun Ulrike, Hellriegel Martin, The journal of obstetrics and gynaecology research . 2019,第7期

机译：抑制有氧糖醇分解，增强了ZOPTARELIN DOXORUBININ在三阴性乳腺癌细胞中的抗肿瘤疗效
4. Simultaneous Delivery of Tocotrienols and Simvastatin by Lipid Nanoemulsion: A Promising Approach for Enhanced Antitumor Activity Against Human Mammary Adenocarcinoma Cells [C] . Mohammad M. Kamal, Ahmed Abu Fayyad, Alaadin Y. Alayoubi, Southern Biomedical Engineering Conference . 2016

机译：脂质纳米乳液同时递送生育三烯酚和辛伐他汀：一种有希望的针对人类乳腺腺癌细胞增强抗肿瘤活性的方法。
5. In Vitro Evaluations of Hexokinase-2 Inhibition with 3-Bromopyruvate Encapsulated in Targeted Liposomal Formulations using 3D Spheroid Models of Tumor Aerobic Glycolysis [D] . Gandham, Srujan Kumar. 2014

机译：用肿瘤有氧糖醇的3D球状模型包封3-溴吡合他分用3-溴吡合他分包封的六酮酶-2抑制的体外评价
6. EGFR signaling enhances aerobic glycolysis in triple negative breast cancer cells to promote tumor growth and immune escape [O] . Seung-Oe Lim, Chia-Wei Li, Weiya Xia, -1

机译：EGFR信号增强三阴性乳腺癌细胞中的有氧糖酵解促进肿瘤生长和免疫逃逸
7. Acquired radioresistance of human tumor cells by DNA-PK/AKT/GSK3β-mediated cyclin D1 overexpression [O] . T Shimura, S Kakuda, Y Ochiai, 2010

机译：通过DNA-PK / AKT /GSK3β介导的细胞周期蛋白D1过度表达获得人肿瘤细胞的辐射敏感度

AKT-mediated enhanced aerobic glycolysis causes acquired radioresistance by human tumor cells

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