Response of human lymphocytes to proton radiation of 60 MeV compared to 250 kV X-rays by the cytokinesis-block micronucleus assay

Miszczyk Justyna; Rawojc Kamila; Panek Agnieszka; Swakon Jan; Prasanna Pataje G.; Rydygier Marzena

首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Response of human lymphocytes to proton radiation of 60 MeV compared to 250 kV X-rays by the cytokinesis-block micronucleus assay

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Response of human lymphocytes to proton radiation of 60 MeV compared to 250 kV X-rays by the cytokinesis-block micronucleus assay

机译：通过胞质分裂阻滞微核试验，与250 kV X射线相比，人类淋巴细胞对60 MeV质子辐射的响应

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Particle radiotherapy such as protons provides a new promising treatment modality to cancer. However, studies on its efficacy and risks are relatively sparse. Using the cytokinesis-blocked micronucleus assay, we characterized response of human peripheral blood lymphocytes, obtained from health donors irradiated in vitro in the dose range: 0-4. 0 Gy, to therapeutic proton radiation of 60 MeV from AIC-144 isochronous cyclotron, by studying nuclear division index and DNA damage and compared them with Xrays.

机译：质子等粒子放射疗法为癌症提供了一种新的有前途的治疗方法。但是，有关其功效和风险的研究相对较少。使用胞质分裂阻滞微核试验，我们表征了人类外周血淋巴细胞的反应，该淋巴细胞得自于体外照射剂量范围为0-4的健康供体。通过研究核分裂指数和DNA损伤并将其与X射线进行比较，将0 Gy从AIC-144等时回旋加速器进行60 MeV的治疗性质子辐射。

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《Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology》 |2015年第1期|共7页
作者
Miszczyk Justyna; Rawojc Kamila; Panek Agnieszka; Swakon Jan; Prasanna Pataje G.; Rydygier Marzena;
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正文语种 eng
中图分类肿瘤学;
关键词
Proton beam; X-rays; Cytokinesis-block micronucleus assay; Human lymphocytes; Micronuclei frequency; Nuclear division index;

机译：质子束;X射线;胞质阻滞微核;人淋巴细胞;微核频率;核分裂指数;

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1. Response of human lymphocytes to proton radiation of 60 MeV compared to 250 kV X-rays by the cytokinesis-block micronucleus assay [J] . Miszczyk Justyna, Rawojc Kamila, Panek Agnieszka, Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology . 2015,第1期

机译：通过胞质分裂阻滞微核试验，与250 kV X射线相比，人类淋巴细胞对60 MeV质子辐射的响应
2. Effects of 60 MeV Protons and 250 kV X-Rays on Cell Viability [J] . Miszczyk J., Panek A., Rawojc K., Acta Physica Polonica . 2016,第2期

机译：60 MeV质子和250 kV X射线对细胞活力的影响
3. Dose estimation with the calibration of dose-response curve of micronucleus in human peripheral lymphocytes induced by 50MeV proton beams [J] . Iranian journal of radiation research : . 2010,第4期

机译：用50mev质子梁诱导人周围淋巴细胞中微核剂量响应曲线的剂量估计
4. CYTOKINESIS BLOCK MICRONUCLEUS IN HUMAN LYMPHOCYTES:EFFECT OF LOW DOSE RADIATION IN VASCULAR RADIOLOGY [C] . M. Alcaraz, B. Rosa, J.L. Navarro, International Conference on Radiological Protection of Patients in Diagnostic and Interventional Radiology, Nuclear Medicine and Radiotherapy, Mar 26-30, 2001, In Malaga, Spain . 2001

机译：人淋巴细胞中的细胞因子阻滞微核：低剂量辐射在血管放射学中的作用
5. Radiographic Proton Imaging Using the Mevion-S250 Radiation Therapy System with Gafchromic Films and Computed Radiography [D] . Wright, Giles. 2018

机译：使用带有全色变色胶片的Mevion-S250放射治疗系统和计算机射线照相技术进行放射线质子成像
6. Delayed Mitogenic Stimulation Decreases DNA Damage Assessed by Micronucleus Assay in Human Peripheral Blood Lymphocytes After 60Co Irradiation [O] . G. Tamizh Selvan, M. Bhavani, J. Vijayalakshmi, 2014

机译：延迟的促有丝分裂刺激减少了60Co辐射后人外周血淋巴细胞中微核分析评估的DNA损伤
7. HUman MicroNucleus Project: International database comparison for results with the cytokinesis-block micronucleus assay in human lymphocytes: I. Effect of laboratory protocol, scoring criteria, and host factors on the frequency of micronuclei [O] . Bonassi Stefano, Fenech Michael, Lando Cecilia, 2001

机译：人类微核素项目：国际数据库比较人类淋巴细胞中胞质分裂阻滞微核分析的结果：I.实验室规程，评分标准和宿主因素对微核频率的影响
8. Radiation-Induced Chromosome Aberrations in Human Lymphocytes. Dose-Response Relationships after Irradiation in Vitro with 200 KV X-Rays and exp 60 Co gamma Rays [R] . Stenstrand, K., Toivonen, H., Rytoemaa, T. 1979

机译：辐射诱导的人淋巴细胞染色体畸变。用200KV X射线和exp 60Coγ射线体外照射后的剂量 - 反应关系

Response of human lymphocytes to proton radiation of 60 MeV compared to 250 kV X-rays by the cytokinesis-block micronucleus assay

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