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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Exhaled nitric oxide predicts radiation pneumonitis in esophageal and lung cancer patients receiving thoracic radiation.
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Exhaled nitric oxide predicts radiation pneumonitis in esophageal and lung cancer patients receiving thoracic radiation.

机译：呼出气一氧化氮可预测接受胸腔放疗的食道癌和肺癌患者发生放射性肺炎。

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BACKGROUND AND PURPOSE: Radiation pneumonitis is a significant toxicity following thoracic radiotherapy with no method to predict individual risk. MATERIALS AND METHODS: Sixty-five patients receiving thoracic radiation for lung or esophageal cancer were enrolled in a phase II study. Each patient received respiratory surveys and exhaled nitric oxide measurements before, on the last day of, and 30-60 days after completing radiotherapy (RT). Pneumonitis toxicity was scored using the common terminology criteria for adverse events, version 4.0. The demographics, dosimetric factors, and nitric oxide ratio (NOR) of end RT/pre-RT were evaluated for correlation with symptomatic patients (Grade >/= 2). RESULTS: Fifty patients completed the trial. The pneumonitis toxicity score was: Grade 3 for 1 patient, Grade 2 for 6 patients, Grade 1 for 18 patients, and Grade 0 for 25 patients. Dosimetric factors were not predictive of symptoms. The NOR was 3.0 +/- 1.8 (range 1.47-6.73) for the symptomatic and 0.78 +/- 0.29 (range 0.33-1.37) for the asymptomatic patients (p=0.006). A threshold NOR of 1.4 separated symptomatic and asymptomatic patients (p<0.001). The average error was 4%. CONCLUSIONS: Elevation in eNO on the last day of radiotherapy predicted subsequent symptomatic radiation pneumonitis weeks to months after treatment.
机译：背景与目的：放射性肺炎是胸部放疗后的一种重要毒性，尚无方法可预测个体风险。材料与方法：65名接受胸腔放疗的肺癌或食管癌患者被纳入II期研究。每位患者在完成放疗（RT）之前，最后一天以及30-60天后接受呼吸检查和呼出气一氧化氮测量。使用4.0版不良事件的通用术语标准对肺炎毒性进行评分。评估终点RT / pre-RT的人口统计学，剂量学因素和一氧化氮比（NOR）与有症状患者的相关性（等级> / = 2）。结果：50名患者完成了该试验。肺炎毒性评分为：1位患者为3级，6位患者为2级，18位患者为1级，25位患者为0级。剂量学因素不能预测症状。有症状患者的NOR为3.0 +/- 1.8（范围1.47-6.73），无症状患者的NOR为0.78 +/- 0.29（范围0.33-1.37）（p = 0.006）。有症状和无症状患者分别为1.4的阈值NOR（p <0.001）。平均误差为4％。结论：放疗最后一天的eNO升高预示了治疗后数周至数月后的症状性放射性肺炎。

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