...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >The Cancer of the Prostate Risk Assessment (CAPRA) in patients treated with external beam radiation therapy: evaluation and optimization in patients at higher risk of relapse.
【24h】

The Cancer of the Prostate Risk Assessment (CAPRA) in patients treated with external beam radiation therapy: evaluation and optimization in patients at higher risk of relapse.

机译：接受外部束放射治疗的患者的前列腺癌风险评估（CAPRA）：对复发风险较高的患者进行评估和优化。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: The Cancer of the Prostate Risk Assessment (CAPRA) was developed to predict freedom from biochemical failure (FFBF) following radical prostatectomy (RP). Its utility following external beam radiation therapy (EBRT) has not been externally evaluated. METHODS: A retrospective study of 612 patients treated with dose-escalated EBRT at the University of Michigan Medical Center. RESULTS: Compared to the derivation cohort, EBRT treated patients had higher-risk disease (28% with CAPRA of 6-10 vs. 5%, respectively). A total of 114 patients (19%) had BF with 5-year BF ranging from 7% with CAPRA 0-3 to 35% with CAPRA 7-10. For RT patients the risk of BF at 5-year was similar to 4 surgical cohorts for CAPRA scores 0-2 but lower for all CAPRA scores >/= 3. The difference favoring RT increased with increasing CAPRA score reaching a 27-50% absolute improved at 5-years for CAPRA scores of 6-10. On multivariate analysis each CAPRA point increased the risk of BF (p<0.0001) while Gleason pattern 5 in the biopsy also increased BF (p=0.01) and long-term androgen deprivation therapy (ADT) significantly reduced the risk of BF (p=0.015). CONCLUSIONS: Compared to surgical series the risk of BF was lower with dose-escalated EBRT with the greatest difference at the highest CAPRA scores.
机译：背景：前列腺癌风险评估（CAPRA）的开发是为了预测前列腺癌根治术（RP）后不会发生生化衰竭（FFBF）。外部束放射治疗（EBRT）后其效用尚未得到外部评估。方法：在密歇根大学医学中心对612例接受剂量递增EBRT治疗的患者进行回顾性研究。结果：与衍生队列相比，EBRT治疗的患者有较高的疾病风险（CAPRA为6-10的患者为28％，而CAPRA的患者为5％）。共有114例患者（19％）患有BF和5年BF，从CAPRA 0-3的7％到CAPRA 7-10的35％。对于RT患者，CAPRA评分0-2的5年高炉风险与4个手术队列相似，但所有> / = 3的CAPRA评分较低。随着CAPRA评分增加，达到绝对值的27-50％，有利于RT的差异增加CAPRA得分为6-10，在5年时有所改善。在多变量分析中，每个CAPRA点均增加了BF的风险（p <0.0001），而活检中的格里森模式5也增加了BF（p = 0.01），长期雄激素剥夺疗法（ADT）显着降低了BF的风险（p = 0.015）。结论：剂量递增的EBRT与外科手术系列相比，发生BF的风险更低，在最高CAPRA评分下差异最大。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号