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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Brachytherapy with permanent gold grain seeds for squamous cell carcinoma of the lip.
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Brachytherapy with permanent gold grain seeds for squamous cell carcinoma of the lip.

机译：用永久性金粒种子进行近距离放射疗法治疗嘴唇鳞状细胞癌。

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PURPOSE: To describe the use of radioactive gold grain implantation for squamous cell carcinoma of the lip. METHODS: Retrospective review of 51 patients treated with permanent gold ((198)Au) grain implant brachytherapy. The seed arrangement delivered a dose of 5500 cGy at 0.5 cm from a single plane. Primary endpoints were local recurrence and cosmetic outcome. RESULTS: Median follow-up was 27 months. Median age was 69 years. The majority (90%) were T1 lesions. None of the patients had evidence of regional lymph node or distant metastasis. Twelve patients had recurrent disease with prior surgery and five patients had previous head and neck radiation. Local control was achieved in 49 patients. Good cosmesis was achieved in 48 patients. Two-year actuarial estimates for local failure-free survival, disease-free survival and overall survival were 97.9%, 94.1% and 87.9%, respectively; no deaths were attributable to lip cancer. CONCLUSIONS: Gold grain interstitial low-dose rate brachytherapy provides excellent local control and cosmesis in patients with squamous cell carcinoma of the lip. This technique provides an excellent option for patients that are elder or live remotely. It is particularly useful for lesions that are small, in previously radiated areas, or treated with prior surgery.
机译：目的：描述放射性金颗粒植入术在唇鳞状细胞癌中的应用。方法：回顾性分析51例接受永久性金（（198）Au）种植体近距离放射治疗的患者。种子排列在距单个平面0.5 cm处递送了5500 cGy的剂量。主要终点是局部复发和美容结局。结果：中位随访时间为27个月。中位年龄为69岁。大多数（90％）是T1病变。没有患者有区域淋巴结转移或远处转移的证据。十二名患者曾接受过外科手术复发性疾病，五名患者曾接受过头颈部放射治疗。 49例患者达到局部控制。 48例患者美容效果良好。两年的局部无故障生存期，无疾病生存期和总生存期的精算估计分别为97.9％，94.1％和87.9％。没有死亡归因于唇癌。结论：金颗粒间质低剂量近距离放射疗法可为唇鳞状细胞癌患者提供出色的局部控制和美容效果。对于年龄较大或偏远的患者，此技术提供了一个极好的选择。对于较小的，在先前辐射的区域或经过先前手术治疗的病变特别有用。

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