Stapled peptides in the p53 pathway: computer simulations reveal novel interactions of the staples with the target protein.

Joseph TL; Lane D; Verma CS

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Stapled peptides in the p53 pathway: computer simulations reveal novel interactions of the staples with the target protein.

机译：p53途径中的吻合肽：计算机模拟显示了吻合钉与靶蛋白的新型相互作用。

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Atomistic simulations of a set of stapled peptides derived from the transactivation domain of p53 (designed by Verdine & colleagues, JACS 2007 129:2456) and complexed to MDM2 reveal that the good binders are uniquely characterized by higher helicity and by extensive interactions between the hydrocarbon staples and the MDM2 surface; in contrast the poor binders have reduced helicity and their staples are mostly solvent exposed. Our studies also find that the best binders can also potentially inhibit MDMX with similar affinities, suggesting that such stapled peptides can be evolved for dual inhibition with therapeutic potential.

机译：对源自p53反式激活域（由Verdine和同事设计，JACS 2007 129：2456设计）并与MDM2结合的一组固定肽的原子模拟显示，良好的结合剂具有独特的特征，即较高的螺旋度和烃之间的广泛相互作用订书钉和MDM2表面;相反，不良的粘合剂降低了螺旋度，并且其订书钉大部分暴露在溶剂中。我们的研究还发现，最好的结合剂还可以潜在地以相似的亲和力抑制MDMX，这表明这种结合肽可以进化为具有治疗潜力的双重抑制作用。

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《Cell cycle》 |2010年第22期|共9页
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Joseph TL; Lane D; Verma CS;
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1. Stapled peptides in the p53 pathway: computer simulations reveal novel interactions of the staples with the target protein. [J] . Joseph TL, Lane D, Verma CS Cell cycle . 2010,第22期

机译：p53途径中的吻合肽：计算机模拟显示了吻合钉与靶蛋白的新型相互作用。
2. Probing theα-helical structural stability of stapled p53 peptides: Molecular dynamics simulations and analysis: Research article [J] . Guo Z., Mohanty U., Noehre J., Chemical biology and drug design . 2010,第4期

机译：探索钉装的p53肽的α-螺旋结构稳定性：分子动力学模拟和分析：研究文章
3. Probing the -Helical Structural Stability of Stapled p53 Peptides: Molecular Dynamics Simulations and Analysis [J] . Zuojun Guo, Udayan Mohanty, Justin Noehre, Chemical Biology & Drug Design . 2010,第4期

机译：探查吻合的p53肽的-螺旋结构稳定性：分子动力学模拟和分析
4. HYDROGEN EXCHANGE-MASS SPECTROMETRY ENABLES THE FACILE MEASUREMENT OF STAPLED PEPTIDE FOLDING DYNAMICS AND OPTIMIZATION OF STAPLED PEPTIDE DRUG PROPERTIES [C] . Xiangguo (Eric) Shi, Thomas E. Wales, Carl Elkin, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2011

机译：氢气交换 - 质谱使得能够进行绒毛肽折叠动力学的嵌合肽动力学和塑料肽药物特性的优化
5. Structural Characterization of BCL-2 Family Protein Interactions Using Photoreactive Stapled Peptides and Mass Spectrometry [D] . Braun, Craig 2012

机译：BCL-2家族蛋白相互作用的结构表征使用光反应性吻合肽和质谱。
6. Reactivation of the p53 Tumor Suppressor Pathway by a Stapled p53 Peptide [O] . Federico Bernal, Andrew F. Tyler, Stanley J. Korsmeyer, -1

机译：装订的p53肽对p53肿瘤抑制因子途径的激活
7. Suppression of p53 response by targeting p53-Mediator binding with a stapled peptide [O] . BL Allen, K Quach, CB Levandowski, 2019

机译：通过靶向p53介体与绒肽结合抑制p53响应

Stapled peptides in the p53 pathway: computer simulations reveal novel interactions of the staples with the target protein.

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