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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Pulsed dose rate brachytherapy in head and neck cancers. Feasibility study of a French cooperative group.
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Pulsed dose rate brachytherapy in head and neck cancers. Feasibility study of a French cooperative group.

机译：头颈癌的脉冲剂量率近距离放射治疗。法国合作集团的可行性研究。

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摘要

PURPOSE: To prospectively evaluate the feasibility of pulsed dose rate (PDR) brachytherapy to mimic the continuous low dose rate (cLDR) iridium wire technique in head and neck carcinomas. MATERIALS AND METHODS: A series of 30 patients were included from June 1995 to May 1998. The primaries were located in the oral cavity (four T1, seven T2 and two T3), the velotonsillar arch (eight T1 and eight T2) and the posterior wall (one T3). Thirteen were irradiated by exclusive brachytherapy (dose, > or =45 Gy). The PDR delivered 0.5 Gy/pulse, one pulse/h, day and night, to mimic cLDR irradiation. RESULTS: The implantation was feasible for all the patients, usually easy and of good quality. The mean duration/pulse was 13 min, with a mean source activity of 171 mCi. Patient tolerance was poor in nine cases. Sixteen patients could receive the whole PDR treatment with a total ranging from 30 to 120 pulses without any problem. Seven had short breakdowns (< or =6 h). Seven had definitive breakdowns, but could end theirradiation by manual afterloading of iridium 192 wires. The radioprotection was better (or complete), except for one patient. Most of the breakdowns were related to kinking or flattering of the tube. CONCLUSIONS: PDR is feasible in head and neck carcinomas, but necessitates improvement of the quality and control of the plastic tubes.
机译：目的：前瞻性评估脉冲剂量率（PDR）近距离放射疗法在头颈癌中模仿连续低剂量率（cLDR）铱线技术的可行性。材料与方法：自1995年6月至1998年5月，共收治了30例患者。原发灶位于口腔（四个T1，七个T2和两个T3），腓肠弓（八个T1和八个T2）和后墙（一个T3）。通过独家近距离放射疗法（剂量≥45 Gy）照射了十三只。 PDR在白天和黑夜以0.5 Gy /脉冲，1脉冲/ h的速度发送信号，以模拟cLDR辐射。结果：对于所有患者而言，植入都是可行的，通常容易且质量良好。平均持续时间/脉冲为13分钟，平均源活性为171 mCi。 9例患者的耐受性差。 16位患者可以接受整个PDR治疗，总脉冲数为30到120，没有任何问题。七个有短暂故障（<或= 6 h）。七个有确定的击穿，但可以通过手动后装铱192线来终止其辐射。除一名患者外，其放射防护较好（或完全）。大多数故障与管的扭结或拉平有关。结论：PDR在头颈癌中是可行的，但有必要提高塑料管的质量和控制。

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