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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Hypoxia imaging with the nitroimidazole 18F-FAZA PET tracer: A comparison with OxyLite, EPR oximetry and 19F-MRI relaxometry
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Hypoxia imaging with the nitroimidazole 18F-FAZA PET tracer: A comparison with OxyLite, EPR oximetry and 19F-MRI relaxometry

机译：使用硝基咪唑18F-FAZA PET示踪剂进行缺氧成像：与OxyLite，EPR血氧饱和度测定法和19F-MRI弛豫测定法进行比较

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Background and purpose: 18F-FAZA is a nitroimidazole PET tracer that can provide images of tumor hypoxia. However, it cannot provide absolute pO 2 values. To qualify 18F-FAZA PET, we compared PET images to pO 2 measured by OxyLite, EPR oximetry and 19F-MRI. Materials and methods: Male WAG/Rij rats grafted with rhabdomyosarcoma were used. Tumor oxygenation was modified by gas breathing (air or carbogen). The same day of PET acquisition, the pO 2 was measured in the same tumor either by OxyLite probes (measurement at 10 different sites), EPR oximetry using low frequency EPR or 19F-relaxometry using 15C5 on an 11.7 T MR system. Results: There was a good correlation between the results obtained by PET and EPR (R = 0.93). In the case of OxyLite, although a weaker correlation was observed (R = 0.55), the trend for two values to agree was still related to the inverse function theoretically predicted. For the comparison of 18F-FAZA PET and 19F-MRI, no change in T 1 was observed. Conclusions: A clear correlation between 18F-FAZA PET image intensities and tumor oxygenation was demonstrated, suggesting that 18F-FAZA PET is a promising imaging technique to guide cancer therapy.
机译：背景与目的：18F-FAZA是一种硝基咪唑PET示踪剂，可提供肿瘤缺氧的图像。但是，它不能提供绝对的pO 2值。为了使18F-FAZA PET合格，我们将PET图像与通过OxyLite，EPR血氧饱和度测定法和19F-MRI测量的pO 2进行了比较。材料与方法：使用雄性WAG / Rij大鼠横纹肌肉瘤移植。通过呼吸（空气或碳源）改变了肿瘤的氧合。在采集PET的同一天，通过OxyLite探针（在10个不同部位进行测量），使用低频EPR的EPR血氧饱和度测定法或使用在11.7 T MR系统上使用15C5的19F松弛法测定同一肿瘤中的pO 2。结果：PET和EPR的结果之间具有良好的相关性（R = 0.93）。在OxyLite的情况下，尽管观察到较弱的相关性（R = 0.55），但两个值一致的趋势仍与理论上预测的逆函数有关。为了比较18F-FAZA PET和19F-MRI，未观察到T 1的变化。结论：18F-FAZA PET图像强度与肿瘤氧合之间存在明显的相关性，这表明18F-FAZA PET是指导癌症治疗的有前途的成像技术。

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