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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Late radiologic changes after stereotactic ablative radiotherapy for early stage lung cancer: A comparison of fixed-beam versus arc delivery techniques
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Late radiologic changes after stereotactic ablative radiotherapy for early stage lung cancer: A comparison of fixed-beam versus arc delivery techniques

机译：早期肺癌的立体定向消融放疗后的晚期放射学变化：固定束与弧形递送技术的比较

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Background and purpose To characterize the radiologic changes occurring following arc stereotactic ablative radiotherapy (SABR) for early-stage non-small cell lung cancer relative to those following fixed-beam SABR. Methods Twenty-nine patients treated with arc SABR without local recurrence and more than two years follow-up were retrospectively evaluated using a published scoring system. The late morphologic patterns, timing and severity of radiologic change were assessed and compared to 54 patients treated with fixed-beam SABR that we previously assessed using the same system. Results The baseline characteristics and follow-up of both cohorts were well matched and SABR technique was not associated with morphologic differences before 6 months (p = 0.23). Thereafter the predicted probabilities of a modified-conventional pattern following arc and fixed-beam SABR were 96.3% vs. 68.9%, respectively (OR 11.7, 95% CI 3.38-40.8, p < 0.001). In addition, at 1 year follow-up the predicted probabilities of arc and fixed-beam SABR patients having expected or pronounced radiologic changes were 64.9% and 22.1%, respectively (OR = 6.56, 95% CI: 3.13-13,7, p < 0.001). Conclusions Post-SABR radiologic changes differ with delivery technique, which has important implications during follow-up. Confirmation in larger studies is required and etiologic factors remain to be determined.
机译：背景与目的相对于固定束SABR术后，对于早期非小细胞肺癌，在弧形立体消融放疗（SABR）之后，进行放射学改变的特征分析。方法使用公开的评分系统回顾性评估29例接受局部SAAR治疗且无局部复发的弧形SABR患者。对晚期形态学特征，放射学改变的时间和严重程度进行了评估，并将其与我们先前使用同一系统评估的54例接受固定束SABR治疗的患者进行了比较。结果两组患者的基线特征和随访情况均吻合良好，并且SABR技术与6个月前的形态学差异无关（p = 0.23）。此后，采用弧线和固定束SABR的修正常规模式的预测概率分别为96.3％和68.9％（OR 11.7，95％CI 3.38-40.8，p <0.001）。此外，在1年的随访中，具有预期或明显影像学改变的弧形和固定束SABR患者的预测概率分别为64.9％和22.1％（OR = 6.56、95％CI：3.13-13,7，p <0.001）。结论SABR后的放射学变化随分娩技术的不同而不同，这在随访期间具有重要意义。需要在较大的研究中进行确认，病因尚待确定。

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