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首页> 外文期刊>Cellular Physiology and Biochemistry >Local Peritonectomy Highly Attracts Free Floating Intraperitoneal Colorectal Tumour Cells in a Rat Model
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Local Peritonectomy Highly Attracts Free Floating Intraperitoneal Colorectal Tumour Cells in a Rat Model

机译：局部腹膜切除术可在大鼠模型中高度吸引自由漂浮的腹膜内结直肠肿瘤细胞

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Background/Aims: Intraperitoneal free cancer cells are associated with a higher risk of recurrence and a poorer prognosis in colorectal surgery. Tumour recurrence may occur early after surgery. One potential mechanism is the ability of peritoneal lesions to attract tumour cells. Methods: In Wag-Rija rats, the parietal peritoneum was resected on a defined area, a corresponding control area was marked in the same rat and colorectal tumour cells (CC531) were applied into the abdomen after surgery. Tissue was harvested 6 or 9 days after surgery to evaluate intra-abdominal tumour growth. Additionally tumour cells were applied 2 weeks after peritoneal resection to investigate tumour growth in a healed area of peritonectomy. Specimens were evaluated for macroscopic tumour spread, weight of the abdominal wall and maximal tumour thickness. Results: Macroscopic tumour spread, weight of the abdominal wall and maximal tumour thickness were significantly increased within the area of peritonectomy after both 6 and 9 days compared to the control area. However, only macroscopic tumour expansion was significantly increased in the healed area of peritonectomy. Conclusion: Peritoneal defects may play an important role in the pathogenesis of tumour implantation and might have some impact on tumour recurrence. The peritoneal damage should be kept as low as possible.
机译：背景/目的：腹膜内游离癌细胞与结直肠癌的复发风险较高且预后较差有关。手术后早期可能会发生肿瘤复发。一种潜在的机制是腹膜病变吸引肿瘤细胞的能力。方法：在Wag-Rija大鼠中，将腹膜腹膜切除在指定区域，在同一只大鼠上标记相应的对照区域，并在手术后将大肠肿瘤细胞（CC531）应用于腹部。手术后6或9天收集组织，以评估腹腔内肿瘤的生长。另外，在腹膜切除术后2周应用肿瘤细胞以研究在腹膜切除术愈合区域中的肿瘤生长。评价标本的宏观肿瘤扩散，腹壁重量和最大肿瘤厚度。结果：与对照组相比，在第6天和第9天腹膜切除术区域内肉眼可见的肿瘤扩散，腹壁重量和最大肿瘤厚度均明显增加。但是，在腹膜切除术的愈合区域，只有肉眼可见的肿瘤扩展明显增加。结论：腹膜缺损可能在肿瘤植入的发病机理中起重要作用，可能对肿瘤的复发有一定影响。腹膜损伤应保持尽可能低。

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