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首页> 外文期刊>Cell cycle >Beyond IP3: roles for higher order inositol phosphates in immune cell signaling.
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Beyond IP3: roles for higher order inositol phosphates in immune cell signaling.

机译：超越IP3：更高级别的肌醇磷酸酯在免疫细胞信号传导中的作用。

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摘要

Nearly 25 years ago the first function of an inositol phosphate, namely Ins(1,4,5)P3, was reported to act as a "second messenger" to mobilize calcium from the endoplasmic reticulum (ER). Since this discovery, many other inositol phosphates and the kinases and phosphatases that generate these inositol phosphates have subsequently been discovered. However, the function of these "higher order" inositol phosphates in biological processes, if any, has remained a mystery. Interest in higher order inositol phosphates, such as Ins(1,3,4,5)P4, was renewed this year following reports of novel roles for these molecules in distinct processes within the immune system ranging from T cell development, B cell development and tolerance induction, as well as neutrophil and mast cell function. In this review, we will touch upon recent advances in inositol phosphate function in mammalian cells. More specifically, we will highlight new studies that have identified novel functions for specific higher order inositol phosphates, such as Ins(1,3,4,5)P4, in the immune system.
机译：大约25年前，据报道磷酸肌醇的第一个功能即Ins（1,4,5）P3充当“第二信使”，从内质网（ER）调集钙。自从发现以来，随后发现了许多其他的肌醇磷酸酯以及产生这些肌醇磷酸酯的激酶和磷酸酶。然而，这些“高阶”肌醇磷酸酯在生物过程中的功能（如果有的话）仍然是个谜。在报道了这些分子在免疫系统的不同过程（从T细胞发育，B细胞发育和免疫）的不同过程中起着新的作用后，今年对Ins（1,3,4,5）P4等更高级磷酸肌醇的兴趣再次引起关注。耐受诱导以及中性粒细胞和肥大细胞功能。在这篇综述中，我们将探讨哺乳动物细胞中磷酸肌醇功能的最新进展。更具体地说，我们将重点介绍一些新的研究，这些研究已经确定了免疫系统中特定的更高阶肌醇磷酸酯（例如Ins（1,3,4,5）P4）的新功能。

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